# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4844594 | B | Protac activity at CRBN/AR in human VCaP cells assessed as AR degradation after 24 hrs by Western blot analysis | Homo sapiens | 40 | ALA4842372 | cell-based format | Scientific Literature | |
2. | ALA4844595 | B | Protac activity at CRBN/AR in human VCaP cells assessed as maximal AR degradation after 24 hrs by Western blot analysis relative to control | Homo sapiens | 40 | ALA4842372 | cell-based format | Scientific Literature | |
3. | ALA4844599 | A | Half life in SCID mouse at 2 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
4. | ALA4844600 | A | AUC (0 to t) in SCID mouse at 2 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
5. | ALA4844601 | A | Volume of distribution at steady state in SCID mouse at 2 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
6. | ALA4844607 | A | Tmax in SCID mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
7. | ALA4844608 | A | Half life in SCID mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
8. | ALA4844609 | A | Cmax in SCID mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
9. | ALA4844610 | A | AUC (0 to t) in SCID mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
10. | ALA4844611 | A | Oral bioavailability in SCID mouse at 5 mg/kg by LC-MS/MS analysis | Mus musculus | 1 | ALA4842372 | organism-based format | Scientific Literature | |
11. | ALA4844612 | F | Growth inhibition of human VCaP cells assessed as cell viability by WST-8 assay | Homo sapiens | 22 | ALA4842372 | cell-based format | Scientific Literature | |
12. | ALA4844613 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as AR degradation after 24 hrs by Western blot analysis | Homo sapiens | 8 | ALA4842372 | cell-based format | Scientific Literature | |
13. | ALA4844614 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as maximal AR degradation after 24 hrs by Western blot analysis relative to control | Homo sapiens | 8 | ALA4842372 | cell-based format | Scientific Literature | |
14. | ALA4844615 | F | Growth inhibition of human LNCaP cells carrying AR T878A mutant assessed as cell viability by WST-8 assay | Homo sapiens | 8 | ALA4842372 | cell-based format | Scientific Literature | |
15. | ALA4844616 | B | Protac activity at CRBN/AR in human VCaP cells assessed as reduction in AR protein level after 6 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA4842372 | cell-based format | Scientific Literature | |
16. | ALA4844617 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as reduction in AR protein level after 6 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA4842372 | cell-based format | Scientific Literature | |
17. | ALA4844618 | B | Protac activity at CRBN/AR in human VCaP cells assessed as reduction in AR protein level after 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA4842372 | cell-based format | Scientific Literature | |
18. | ALA4844619 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as reduction in AR protein level after 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | ALA4842372 | cell-based format | Scientific Literature | |
19. | ALA4844620 | F | Antitumor activity against human VCaP cells xenografted in CB17:SCID mouse assessed as reduction in AR protein level in tumor at 20 mg/kg, po measured for 6 to 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4842372 | organism-based format | Scientific Literature | |
20. | ALA4844621 | A | Drug distribution in plasma of CB17:SCID mouse xenografted with human VCaP cells at 20 mg/kg, po measured at 6 hrs by LCMS analysis | Mus musculus | 4 | ALA4842372 | organism-based format | Scientific Literature |