| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4823336 | B | Inhibition of HDAC in human A2780 cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 18 hrs followed by susbtrate addition and measured after 3 hrs by fluorescence microplate reader assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 2. | ALA4823337 | B | Inhibition of HDAC in human CAL-27 cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 18 hrs followed by susbtrate addition and measured after 3 hrs by fluorescence microplate reader assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 3. | ALA4823338 | F | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 4. | ALA4823339 | F | Antiproliferative activity against human CAL-27 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA4823340 | B | Inhibition of recombinant human full length C-terminal GST-fusion tagged HDAC2 expressed in baculovirus infected insect cells using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 90 mins by fluorimetry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4823341 | B | Inhibition of recombinant human N-terminal GST-fusion tagged/C-terminal GST-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 90 mins by fluorimetry | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA4823342 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in baculovirus infected insect cells using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 90 mins by fluorimetry | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA4823343 | B | Inhibition of recombinant human C-terminal His-fusion tagged/N-terminal Strep2 tagged HDAC8 (1 to 377 residues) expressed in insect cells using Boc-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 90 mins by fluorimetry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA4823344 | B | Inhibition of class-1 HDAC in human CAL-27 cells assessed as induction of histone H-3 acetylation at 5 uM for 24 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4823345 | F | Induction of histone H-3 expression in human CAL-27 cells for 24 hrs by Western blot analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 11. | ALA4823348 | F | Induction of apoptosis in human CAL-27 cells assessed as caspase 3 activation at 2 uM in presence of pretreated for 24 hrs followed by cisplatin treatment and further incubated for 18 hrs by Caspase3/7 detection reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4823349 | F | Induction of apoptosis in human CAL-27 cells assessed as caspase 7 activation at 2 uM in presence of pretreated for 24 hrs followed by cisplatin treatment and further incubated for 18 hrs by Caspase3/7 detection reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4823352 | F | Induction of apoptosis in cisplatin resistant human CAL-27 cells assessed as caspase 3 activation at 2 uM pretreated for 24 hrs followed by cisplatin treatment and further incubated for 18 hrs by Caspase3/7 detection reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4823353 | F | Induction of apoptosis in cisplatin resistant human CAL-27 cells assessed as caspase 7 activation at 2 uM in presence cisplatin of pretreated for 24 hrs followed by cisplatin treatment and further incubated for 18 hrs by Caspase3/7 detection reagent based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4823354 | F | Induction of DNA damage in human CAL-27 cells assessed as increase in gamma H2AX phosphorylation pretreated for 24 hrs followed by cisplatin treatment and further incubated for 18 hrs measured by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4823355 | F | Induction of DNA damage in human Cal27CisR cells assessed as increase in gamma H2AX phosphorylation pretreated for 24 hrs followed by cisplatin treatment and further incubated for 18 hrs measured by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4823356 | F | Induction of DNA damage human human Cal27CisR cells assessed as upregulation of gamma H2AX in presence cisplatin measured by Western blot analysis | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 18. | ALA4823357 | F | Induction of DNA damage in human CAL-27 cells assessed as upregulation of gamma H2AX in presence cisplatin measured by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4823358 | B | Inhibition of Class 1/2b HDAC in human HL-60 cells by HDAC-Glo assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4823359 | F | Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability for 72 hrs by Celltitre-Glo luminescent assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
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