| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4828505 | ADME | Microsomal stability in human liver microsomes assessed as intrinsic clearance at 100 uM preincubated for 10 mins with NADPH followed by compound addition and measured upto 30 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4825765 | microsome format | Scientific Literature | |
| 2. | ALA4828506 | ADME | Microsomal stability in mouse liver microsomes assessed as half life at 100 uM preincubated for 10 mins with NADPH followed by compound addition and measured upto 30 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | microsome format | Scientific Literature | |
| 3. | ALA4828507 | ADME | Microsomal stability in rat liver microsomes assessed as half life at 100 uM preincubated for 10 mins with NADPH followed by compound addition and measured upto 30 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4825765 | microsome format | Scientific Literature | |
| 4. | ALA4828508 | ADME | Microsomal stability in human liver microsomes assessed as half life at 100 uM preincubated for 10 mins with NADPH followed by compound addition and measured upto 30 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4825765 | microsome format | Scientific Literature | |
| 5. | ALA4828509 | ADME | Volume of distribution at steady state in CD1 mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 6. | ALA4828510 | ADME | AUC in CD1 mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 7. | ALA4828511 | ADME | Clearance in CD1 mouse at 2 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 8. | ALA4828512 | ADME | Oral bioavailability in CD1 mouse at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 9. | ALA4828513 | ADME | Cmax in CD1 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 10. | ALA4828514 | ADME | AUC in CD1 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 11. | ALA4828515 | ADME | Half life in CD1 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | organism-based format | Scientific Literature | |
| 12. | ALA4828516 | ADME | Drug concentration in plasma of mouse at 25 mg/kg, po administered as single dose after 6 hrs by LC-MS/MS analysis | Mus musculus | 17 | ALA4825765 | organism-based format | Scientific Literature | |
| 13. | ALA4828517 | ADME | Drug concentration in plasma of mouse at 25 mg/kg, po administered as single dose after 3 hrs by LC-MS/MS analysis | Mus musculus | 17 | ALA4825765 | organism-based format | Scientific Literature | |
| 14. | ALA4828518 | ADME | Drug concentration in plasma of mouse at 25 mg/kg, po administered as single dose after 1 hr by LC-MS/MS analysis | Mus musculus | 17 | ALA4825765 | organism-based format | Scientific Literature | |
| 15. | ALA4828519 | Functional | Growth inhibition of human KARPAS-422 cells assessed as cell growth incubated for 7 days by lactate dehydrogenase based WST-8 assay | Homo sapiens | 35 | ALA4825765 | cell-based format | Scientific Literature | |
| 16. | ALA4828520 | Binding | Inhibition of biotinylated H3K27Me3 peptide (19 to 33 residues) binding to His-tagged EED (1 to 441 residues) (unknown origin) preincubated for 15 mins followed by H3K27Me3 addition and measured after 30 mins by alphascreen competition binding assay | Homo sapiens | 35 | ALA4825765 | single protein format | Scientific Literature | |
| 17. | ALA4828521 | ADME | Microsomal stability in rat liver microsomes assessed as intrinsic clearance at 100 uM preincubated for 10 mins with NADPH followed by compound addition and measured upto 30 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4825765 | microsome format | Scientific Literature | |
| 18. | ALA4828522 | ADME | Microsomal stability in mouse liver microsomes assessed as intrinsic clearance at 100 uM preincubated for 10 mins with NADPH followed by compound addition and measured upto 30 mins by LC-MS/MS analysis | Mus musculus | 3 | ALA4825765 | microsome format | Scientific Literature | |
| 19. | ALA4828523 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 3 | ALA4825765 | single protein format | Scientific Literature | |
| 20. | ALA4828524 | ADME | Inhibition of CYP2B6 (unknown origin) | Homo sapiens | 3 | ALA4825765 | single protein format | Scientific Literature |
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