| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4816951 | F | Induction of apoptosis in human MCF7 cells assessed as increase in cleaved caspase-9 level at 2 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA4813989 | cell-based format | Scientific Literature | |
| 2. | ALA4816952 | B | Inhibition of MDM2 in human MCF7 cells assessed as increase in p53 accumulation at 0.5 to 2 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 3. | ALA4816953 | B | Binding affinity in GPX4 in human MCF7 cells assessed as increase in stability in 60 and 65 degreeC at 100 uM by cellular thermal shift assay | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 4. | ALA4816954 | B | Inhibition of MDM2 (unknown origin) using peptide as substrate incubated for 30 mins by fluorescence polarization assay | Homo sapiens | 31 | ALA4813989 | single protein format | Scientific Literature | |
| 5. | ALA4816955 | A | Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay | Homo sapiens | 30 | ALA4813989 | cell-based format | Scientific Literature | |
| 6. | ALA4816956 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay | Homo sapiens | 32 | ALA4813989 | cell-based format | Scientific Literature | |
| 7. | ALA4816957 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs in presence of Fer-1 by CCK8 assay | Homo sapiens | 32 | ALA4813989 | cell-based format | Scientific Literature | |
| 8. | ALA4816958 | F | Selectivity index, ratio of IC50 for antiproliferative activity against human MCF7 cells in presence of Fer-1 to IC50 for antiproliferative activity against human MCF7 cells | Homo sapiens | 32 | ALA4813989 | cell-based format | Scientific Literature | |
| 9. | ALA4816959 | B | Inhibition of MDM2 in human MCF7 cells assessed as increase in MDM2 accumulation at 0.5 to 2 uM incubated for 48 hrs by Western blot analysis | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 10. | ALA4816962 | B | Inhibition of GPX4 in human MCF7 cells assessed as increase in GPX4 degradation incubated for 48 hrs by Western blot analysis | Homo sapiens | 2 | ALA4813989 | cell-based format | Scientific Literature | |
| 11. | ALA4816963 | F | Induction of apoptosis in human MCF7 cells assessed as viable cells at 0.1 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 93.1 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 12. | ALA4816964 | F | Induction of apoptosis in human MCF7 cells assessed as early apoptotic cells at 0.1 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 1.05 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 13. | ALA4816965 | F | Induction of apoptosis in human MCF7 cells assessed as late apoptotic cells at 0.1 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 2.61 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 14. | ALA4816966 | F | Induction of apoptosis in human MCF7 cells assessed as necrotic cells at 0.1 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 3.21 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 15. | ALA4816967 | F | Induction of apoptosis in human MCF7 cells assessed as viable cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 93.1 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 16. | ALA4816968 | F | Induction of apoptosis in human MCF7 cells assessed as early apoptotic cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 1.05 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 17. | ALA4816969 | F | Induction of apoptosis in human MCF7 cells assessed as late apoptotic cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 2.61 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 18. | ALA4816970 | F | Induction of apoptosis in human MCF7 cells assessed as necrotic cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 3.21 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 19. | ALA4816971 | F | Induction of apoptosis in human MCF7 cells assessed as viable cells at 1 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 93.1 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature | |
| 20. | ALA4816972 | F | Induction of apoptosis in human MCF7 cells assessed as early apoptotic cells at 1 uM incubated for 48 hrs by annexin-V-FITC and PI staining based flow cytometry analysis (Rvb = 1.05 %) | Homo sapiens | 1 | ALA4813989 | cell-based format | Scientific Literature |
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