# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831254 | A | Volume of distribution at steady state in rat | Rattus norvegicus | 1 | ALA4828767 | assay format | Scientific Literature | |
2. | ALA4831255 | A | Half life in rat | Rattus norvegicus | 1 | ALA4828767 | assay format | Scientific Literature | |
3. | ALA4831256 | A | Oral bioavailability in rat | Rattus norvegicus | 1 | ALA4828767 | organism-based format | Scientific Literature | |
4. | ALA4831257 | B | Inhibition of N-terminal His6-tagged human p70S6k T412E mutant (1 to 421 residues) expressed in Sf21 cells using FITC-AHA-AKRRRLSSLRA-OH as substrate incubated for 90 mins by mobility shift assay | Homo sapiens | 48 | ALA4828767 | cell-based format | Scientific Literature | |
5. | ALA4831258 | B | Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mobility shift assay | Homo sapiens | 18 | ALA4828767 | assay format | Scientific Literature | |
6. | ALA4831259 | B | Inhibition of PI3K/Akt/mTOR pathway in human MDA-MB-468 cells assessed as reduction in S6 phosphorylation incubated for 15 to 20 mins by Alexa Fluor 488 staining based assay | Homo sapiens | 18 | ALA4828767 | cell-based format | Scientific Literature | |
7. | ALA4831260 | B | Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP (803 to 918 residues) in baculovirus infected Sf21 cells incubated for 90 mins by mobility shift assay | Homo sapiens | 15 | ALA4828767 | cell-based format | Scientific Literature | |
8. | ALA4831263 | A | Intrinsic clearance in mouse microsomes | Mus musculus | 2 | ALA4828767 | microsome format | Scientific Literature | |
9. | ALA4831264 | A | Intrinsic clearance in rat microsomes | Rattus norvegicus | 2 | ALA4828767 | microsome format | Scientific Literature | |
10. | ALA4831265 | A | Intrinsic clearance in human microsomes | Homo sapiens | 2 | ALA4828767 | microsome format | Scientific Literature | |
11. | ALA4831266 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 2 | ALA4828767 | cell-based format | Scientific Literature | |
12. | ALA4831267 | A | Protein binding in mouse plasma assessed as unbound fraction | Mus musculus | 2 | ALA4828767 | cell-free format | Scientific Literature | |
13. | ALA4831268 | A | Protein binding in rat plasma assessed as unbound fraction | Rattus norvegicus | 2 | ALA4828767 | cell-free format | Scientific Literature | |
14. | ALA4831269 | A | Protein binding in human plasma assessed as unbound fraction | Homo sapiens | 2 | ALA4828767 | cell-free format | Scientific Literature | |
15. | ALA4831272 | A | Clearance in mouse | Mus musculus | 2 | ALA4828767 | organism-based format | Scientific Literature | |
16. | ALA4831273 | A | Half life in mouse | Mus musculus | 2 | ALA4828767 | organism-based format | Scientific Literature | |
17. | ALA4831274 | A | Volume of distribution at steady state in mouse | Mus musculus | 1 | ALA4828767 | organism-based format | Scientific Literature | |
18. | ALA4831275 | B | Selectivity ratio of IC50 for GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP (803 to 918 residues) in baculovirus infected Sf21 cells to N-terminal His6-tagged human p70S6k T412E mutant (1 to 421 residues) expressed in Sf21 cells | Homo sapiens | 11 | ALA4828767 | cell-based format | Scientific Literature | |
19. | ALA4831276 | A | Oral bioavailability in mouse | Mus musculus | 2 | ALA4828767 | organism-based format | Scientific Literature | |
20. | ALA4831277 | B | Inhibition of PKA (unknown origin) at 1 uM relative to control | Homo sapiens | 1 | ALA4828767 | assay format | Scientific Literature |