Antitumor activity against mouse MC38 cells inoculated C57BL/6 mouse syngeneic model assessed as tumor growth inhibition at 100 mg/kg, po twice a day for 2 weeks by five days on/two days off schedule relative to control
Immunomodulatory activity in mouse MC38 cells inoculated C57BL/6 mouse syngeneic model assessed as increase in M1 to M2 like TAM ratio in tumor at 100 mg/kg, po twice a day for 2 weeks by five days on/two days off schedule relative to control
Immunomodulatory activity in mouse MC38 cells inoculated C57BL/6 mouse syngeneic model assessed as decrease in M1 like TAM (CD86+ CD11b+ F4/80+)at 100 mg/kg, po twice a day for 2 weeks by five days on/two days off schedule relative to control
Immunomodulatory activity in mouse MC38 cells inoculated C57BL/6 mouse syngeneic model assessed as decrease in M2 like TAM (CD206+ CD11b F4/80+) at 100 mg/kg, po twice a day for 2 weeks by five days on/two days off schedule relative to control
Immunomodulatory activity in mouse MC38 cells inoculated C57BL/6 mouse syngeneic model assessed as increase in cytotoxic CD8+ T cell to M2 like TAM ratio in tumor at 100 mg/kg, po twice a day for 2 weeks by five days on/two days off schedule relative to control
Toxicity in C57BL/6 mouse inoculated with mouse MC38 cells assessed as body weight loss at 100 mg/kg, po twice a day for 2 weeks by five days on/two days off schedule relative to control