| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4823673 | B | Protac activity at SHP2/CRBN in human MV4-11 cells assessed as SHP2 degradation at 8 nM measured after 12 hrs by Western blot analysis relative to control | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 2. | ALA4823674 | B | Protac activity at SHP2/CRBN in human MV4-11 cells assessed as SHP2 degradation at 200 nM measured after 12 hrs by Western blot analysis relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 3. | ALA4823675 | B | Protac activity at SHP2/CRBN in human MV4-11 cells assessed as decrease in SHP2 protein level measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4823676 | B | Protac activity at SHP2/CRBN in human MV4-11 cells assessed as induction of SHP2 degradation measured after 12 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4823677 | B | Protac activity at SHP2/CRBN in human MV4-11 cells assessed as SHP2 degradation at 100 nM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4823678 | B | Protac activity at SHP2/CRBN in human MV4-11 cells assessed as SHP2 degradation at 100 nM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4823679 | F | Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4823680 | B | Inhibition of human SHP2 catalytic activity in human MV4-11 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4823681 | F | Cell cycle arrest in human MV4-11 cells assessed as accumulation at G1 phase measured after 24 hrs by PI staining based flow cytometry assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4823682 | F | Induction of apoptosis in human MV4-11 cells assessed as viable cells at 70 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 91%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4823683 | F | Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 70 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 2.99%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4823684 | F | Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 70 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 5.95%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4823685 | F | Induction of apoptosis in human MV4-11 cells assessed as necrotic cells at 70 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 0.07%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4823686 | F | Induction of apoptosis in human MV4-11 cells assessed as viable cells at 200 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 91%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4823687 | F | Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 200 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 2.99%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4823688 | F | Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 200 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 5.95%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4823689 | F | Induction of apoptosis in human MV4-11 cells assessed as necrotic cells at 200 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 0.07%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4823690 | F | Induction of apoptosis in human MV4-11 cells assessed as viable cells at 600 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 91%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4823691 | F | Induction of apoptosis in human MV4-11 cells assessed as early apoptotic cells at 600 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 2.99%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4823692 | F | Induction of apoptosis in human MV4-11 cells assessed as late apoptotic cells at 600 nM measured after 48 hrs by Annexin V/FITC-PI staining based flowcytometry assay (Rvb = 5.95%) | Homo sapiens | 2 | cell-based format | Scientific Literature |
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