| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4834652 | B | Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentration 9 nM using Arg-AMC as substrate preincubated for 15 mins followed by substrate addition and measured every 10 mins for 300 mins by fluorescence based assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 2. | ALA4834661 | B | Inhibition of LTA4H in human whole blood assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation preincubated for 15 mins followed by ionophore stimulation and measured after 15 hrs by EIA assay | Homo sapiens | 25 | tissue-based format | Scientific Literature | ||
| 3. | ALA4834667 | B | Displacement of [3H]WIN35428 from recombinant human dopamine transporter by radioligand binding assay | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 4. | ALA4834668 | P | Solubility of compound in aqueous buffer at pH 6.8 by HPLC analysis | 15 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4834669 | F | Ex-vivo inhibition of LTA4H in blood isolated from C57/BL6 mouse assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation at 10 mg/kg, po measured after 14 hrs by EIA assay | Mus musculus | 15 | organism-based format | Scientific Literature |
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