# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825887 | Functional | Antiviral activity against Respiratory syncytial virus A2 infected in African green monkey Vero cells by Plaque reduction assay | Human respiratory syncytial virus | 21 | ALA4825662 | organism-based format | Scientific Literature | |
2. | ALA4825888 | ADME | Cytotoxicity against African green monkey Vero cells by MTT assay | Chlorocebus sabaeus | 17 | ALA4825662 | cell-based format | Scientific Literature | |
3. | ALA4825890 | ADME | Apparent permeability of compound in wild type MDCK at 10 uM incubated for 1 hr by LC-MS/MS assay | Canis lupus familiaris | 3 | ALA4825662 | tissue-based format | Scientific Literature | |
4. | ALA4825891 | ADME | Protein binding in rat plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Rattus norvegicus | 12 | ALA4825662 | cell-free format | Scientific Literature | |
5. | ALA4825892 | ADME | Protein binding in dog plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Canis lupus familiaris | 12 | ALA4825662 | cell-free format | Scientific Literature | |
6. | ALA4825893 | ADME | Protein binding in human plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Homo sapiens | 12 | ALA4825662 | cell-free format | Scientific Literature | |
7. | ALA4825894 | ADME | Intrinsic clearance in Sprague-Dawley rat liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 12 | ALA4825662 | microsome format | Scientific Literature | |
8. | ALA4825895 | ADME | Intrinsic clearance in Beagle dog liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA4825662 | microsome format | Scientific Literature | |
9. | ALA4825896 | ADME | Intrinsic clearance in human liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4825662 | microsome format | Scientific Literature | |
10. | ALA4825906 | Binding | Inhibition of Respiratory syncytial virus A2 fusion protein expressed in HEK293T cells harboring GAL4-NF-kappaB assessed as reduction in cell-cell fusion by luciferase assay | Human respiratory syncytial virus A2 | 24 | ALA4825662 | cell-based format | Scientific Literature | |
11. | ALA4825907 | Physicochemical | Thermodynamic solubility in PBS at 1 to 100 uM at pH 7.4 by HPLC-UV method | 11 | ALA4825662 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4825911 | ADME | Intrinsic clearance in rat hepatocytes assessed per million cells at 3 uM measured up to 60 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4825662 | cell-based format | Scientific Literature |