# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4828188 | B | Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
2. | ALA4828189 | A | Inhibition of recombinant human N-terminal His6-tagged full length P110alpha/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
3. | ALA4828190 | A | Inhibition of recombinant human N-terminal His6-tagged full length P110beta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
4. | ALA4828191 | B | Inhibition of recombinant human N-terminal His6-tagged full length P120gamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
5. | ALA4828192 | B | Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytostim stimulation and measured after 20 hrs by electrochemiluminescence assay | Homo sapiens | 34 | tissue-based format | Scientific Literature | ||
6. | ALA4828193 | A | Binding affinity to human serum albumin by HPLC analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
7. | ALA4828195 | B | Selectivity ratio of IC50 for inhibition of recombinant human N-terminal His6-tagged full length P120gamma expressed in baculovirus infected Sf21 insect cells to IC50 for inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4828196 | B | Selectivity ratio of IC50 for inhibition of recombinant human N-terminal His6-tagged full length P110alpha/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells to IC50 for inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4828197 | B | Selectivity ratio of IC50 for inhibition of recombinant human N-terminal His6-tagged full length P110beta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells to IC50 for inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4828198 | B | Inhibition of PI3Kdelta in human HL-60 cell extract measured after 2 hrs by kinobeads based chemoproteomic competition binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
11. | ALA4828199 | A | Inhibition of VPS34 in human HL-60 cell extract measured after 2 hrs by kinobeads based chemoproteomic competition binding assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
12. | ALA4828200 | B | Selectivity ratio of IC50 for inhibition of VPS34 in human HL-60 cell extract to IC50 for inhibition of PI3Kdelta in human HL-60 cell extract | Homo sapiens | 30 | assay format | Scientific Literature | ||
13. | ALA4828201 | B | Inhibition of human ERG | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA4828202 | P | Solubility in pH 6.5 FaSSIF incubated for 4 hrs using amorphous form of sample by UV-HPLC method | 1 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA4828203 | P | Lipophilicity, log D of compound by chromatographic method | 30 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA4828204 | A | Intrinsic clearance in Wistar Han rat liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 30 | microsome format | Scientific Literature | ||
17. | ALA4828205 | A | Intrinsic clearance in pooled human liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | microsome format | Scientific Literature | ||
18. | ALA4828206 | A | Clearance in Wistar Han rat at 1 mg/kg, iv administered as infusion for 1 hr by RP LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
19. | ALA4828207 | A | Volume of distribution at steady state in Wistar Han rat at 1 mg/kg, iv administered as infusion for 1 hr by RP LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
20. | ALA4828208 | A | Half life in Wistar Han rat at 1 mg/kg, iv administered as infusion for 1 hr by RP LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature |