# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4818719 | Binding | Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's method | Homo sapiens | 30 | ALA4814070 | single protein format | Scientific Literature | |
2. | ALA4818720 | Binding | Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's method | Homo sapiens | 29 | ALA4814070 | single protein format | Scientific Literature | |
3. | ALA4818721 | ADME | Ratio of drug level in brain to plasma in ICR mouse at 5 mg/kg, ip measured after 15 mins by HPLC-MS analysis | Mus musculus | 6 | ALA4814070 | organism-based format | Scientific Literature | |
4. | ALA4818723 | ADME | Drug uptake in ICR mouse plasma at 5 mg/kg, ip measured after 15 mins by HPLC-MS analysis | Mus musculus | 6 | ALA4814070 | organism-based format | Scientific Literature | |
5. | ALA4818724 | Binding | Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV holding potential by whole-cell patch clamp method | Homo sapiens | 31 | ALA4814070 | cell-based format | Scientific Literature | |
6. | ALA4818726 | Binding | Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV holding potential by whole-cell patch clamp method | Homo sapiens | 31 | ALA4814070 | cell-based format | Scientific Literature | |
7. | ALA4818727 | Binding | Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current at 100 uM measured at +40 mV holding potential by whole-cell patch clamp method | Homo sapiens | 30 | ALA4814070 | cell-based format | Scientific Literature | |
8. | ALA4818728 | Binding | Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current at 100 uM measured at +40 mV holding potential by whole-cell patch clamp method | Homo sapiens | 31 | ALA4814070 | cell-based format | Scientific Literature | |
9. | ALA4818729 | Binding | Selectivity index, ratio of IC50 for human plasmatic BuChE to IC50 for human recombinant AChE | Homo sapiens | 29 | ALA4814070 | assay format | Scientific Literature | |
10. | ALA4818730 | Binding | Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at +40 mV holding potential by whole-cell patch clamp method | Homo sapiens | 8 | ALA4814070 | cell-based format | Scientific Literature | |
11. | ALA4818731 | Binding | Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at +40 mV holding potential by whole-cell patch clamp method | Homo sapiens | 8 | ALA4814070 | cell-based format | Scientific Literature | |
12. | ALA4818732 | ADME | Drug uptake in ICR mouse brain at 5 mg/kg, ip measured after 15 mins by HPLC-MS analysis | Mus musculus | 6 | ALA4814070 | organism-based format | Scientific Literature | |
13. | ALA4818733 | ADME | Drug uptake in ICR mouse plasma at 5 mg/kg, ip measured after 60 mins by HPLC-MS analysis | Mus musculus | 6 | ALA4814070 | organism-based format | Scientific Literature | |
14. | ALA4818734 | ADME | Drug uptake in ICR mouse brain at 5 mg/kg, ip measured after 60 mins by HPLC-MS analysis | Mus musculus | 6 | ALA4814070 | organism-based format | Scientific Literature |