# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4844594 | B | Protac activity at CRBN/AR in human VCaP cells assessed as AR degradation after 24 hrs by Western blot analysis | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
2. | ALA4844595 | B | Protac activity at CRBN/AR in human VCaP cells assessed as maximal AR degradation after 24 hrs by Western blot analysis relative to control | Homo sapiens | 40 | cell-based format | Scientific Literature | ||
3. | ALA4844596 | A | Half life in SCID mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
4. | ALA4844597 | A | AUC (0 to t) in SCID mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
5. | ALA4844598 | A | Volume of distribution at steady state in SCID mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
6. | ALA4844602 | A | Tmax in SCID mouse at 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
7. | ALA4844603 | A | Half life in SCID mouse at 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
8. | ALA4844604 | A | Cmax in SCID mouse at 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
9. | ALA4844605 | A | AUC (0 to t) in SCID mouse at 3 mg/kg, po by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
10. | ALA4844606 | A | Oral bioavailability in SCID mouse at 3 mg/kg by LC-MS/MS analysis | Mus musculus | 7 | organism-based format | Scientific Literature | ||
11. | ALA4844612 | F | Growth inhibition of human VCaP cells assessed as cell viability by WST-8 assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
12. | ALA4844613 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as AR degradation after 24 hrs by Western blot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
13. | ALA4844614 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as maximal AR degradation after 24 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
14. | ALA4844615 | F | Growth inhibition of human LNCaP cells carrying AR T878A mutant assessed as cell viability by WST-8 assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
15. | ALA4844616 | B | Protac activity at CRBN/AR in human VCaP cells assessed as reduction in AR protein level after 6 hrs by Western blot analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
16. | ALA4844617 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as reduction in AR protein level after 6 hrs by Western blot analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
17. | ALA4844618 | B | Protac activity at CRBN/AR in human VCaP cells assessed as reduction in AR protein level after 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
18. | ALA4844619 | B | Protac activity at CRBN/AR T878A mutant in human LNCaP cells assessed as reduction in AR protein level after 24 hrs by Western blot analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
19. | ALA4844620 | F | Antitumor activity against human VCaP cells xenografted in CB17:SCID mouse assessed as reduction in AR protein level in tumor at 20 mg/kg, po measured for 6 to 24 hrs by Western blot analysis | Homo sapiens | 3 | organism-based format | Scientific Literature | ||
20. | ALA4844621 | A | Drug distribution in plasma of CB17:SCID mouse xenografted with human VCaP cells at 20 mg/kg, po measured at 6 hrs by LCMS analysis | Mus musculus | 4 | organism-based format | Scientific Literature |