# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4826670 | T | Mutagenicity in Salmonella typhimurium TA100 in presence of rat liver S9 fraction by AMES test | Salmonella enterica subsp. enterica serovar Typhimurium | 9 | subcellular format | Scientific Literature | ||
2. | ALA4826671 | B | Positive allosteric modulator activity at alpha3beta4 nAChR (unknown origin) upto 10 uM by automated Q-patch clamp assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
3. | ALA4826672 | B | Agonist activity at alpha3beta4 nAChR (unknown origin) upto 30 uM by automated Q-patch clamp assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
4. | ALA4826674 | A | Ratio of drug level in Wistar rat brain to plasma at 10 mg/kg, ip measured after 35 mins by HPLC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
5. | ALA4826675 | A | Ratio of drug level in Wistar rat brain to plasma at 3 mg/kg, ip measured after 35 mins by HPLC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
6. | ALA4826676 | A | Ratio of drug level in Wistar rat brain to plasma at 1 mg/kg, ip measured after 35 mins by HPLC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
7. | ALA4826677 | A | Apparent permeability across apical to basolateral side in vinblastine-treated human Caco-2 cells expressing P-glycoprotein at 10 uM incubated for 120 mins by HPLC analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
8. | ALA4826678 | B | Activation of human alpha5beta3gamma2 GABAA receptor expressed in HEK293 cells assessed as enhancement of GABA induced channel current response at 1 to 10 uM measured after 7 to 10 mins at -80 mV holding potential by whole-cell patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4826679 | B | Inhibition of human alpha5beta3gamma2 GABAA receptor expressed in HEK293 cells assessed as inhibition of GABA induced channel current response at 1 to 10 uM measured after 7 to 10 mins at -80 mV holding potential by whole-cell patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4826680 | B | Activation of human alpha1beta3gamma2 GABAA receptor expressed in HEK293 cells assessed as enhancement of GABA induced channel current response at 1 to 10 uM measured after 7 to 10 mins at -80 mV holding potential by whole-cell patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4826682 | B | Inhibition of human alpha1beta3gamma2 GABAA receptor expressed in HEK293 cells assessed as inhibition of GABA induced channel current response at 1 to 10 uM measured after 7 to 10 mins at -80 mV holding potential by whole-cell patch clamp assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4826683 | F | Cognitive enhancing effect in scopolamine-induced amnesia NMRI mouse model assessed as increase in recognition index at 1 to 10 mg/kg, ip administered 30 mins prior to scopolamine injection by Y-maze test | Mus musculus | 4 | organism-based format | Scientific Literature | ||
13. | ALA4826684 | P | Kinetic solubility of compound | 44 | small-molecule physicochemical format | Scientific Literature | |||
14. | ALA4826685 | B | Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU282987-induced calcium influx measured after 10 mins by FLIPR assay | Homo sapiens | 46 | cell-based format | Scientific Literature | ||
15. | ALA4826687 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM measured per mg protein upto 40 mins | Homo sapiens | 33 | microsome format | Scientific Literature | ||
16. | ALA4826688 | A | Metabolic stability in Wistar rat liver microsomes assessed as intrinsic clearance at 1 uM measured per mg protein upto 40 mins | Rattus norvegicus | 24 | microsome format | Scientific Literature | ||
17. | ALA4826689 | A | Metabolic stability in NMRI mouse liver microsomes assessed as intrinsic clearance at 1 uM measured per mg protein upto 40 mins | Mus musculus | 24 | microsome format | Scientific Literature | ||
18. | ALA4826690 | B | Positive allosteric modulation of human alpha7 nAChR expressed in HEK293 cells assessed as inhibition of choline-evoked current desensitization measured after 6 to 10 mins at -80 mV holding potential by automated whole cell patch clamp analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4826691 | B | Binding affinity to human recombinant 5-HT2B receptor assessed as displacement of radioligand at 10 uM by displacement binding assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
20. | ALA4826692 | B | Binding affinity to human recombinant sigma-1 receptor assessed as displacement of radioligand at 10 uM by displacement binding assay | Homo sapiens | 1 | single protein format | Scientific Literature |