| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4809906 | A | Displacement of Alexa Fluor 647 labelled ligand from 6His-Thr tagged BRD4 BD1/BD2 Y390A mutant (1 to 477 residue) (unknown origin) measured after 30 mins by TR-FRET assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
| 2. | ALA4809907 | B | Displacement of Alexa Fluor 647 labelled ligand from 6His-Thr tagged BRD4 BD2/BD1 Y97A mutant (1 to 477 residue) (unknown origin) measured after 30 mins by TR-FRET assay | Homo sapiens | 43 | single protein format | Scientific Literature | ||
| 3. | ALA4809908 | B | Selectivity index, ratio of IC50 for displacement of Alexa Fluor 647 labelled ligand from 6His-tagged BRD4 BD1 (1 to 477 residue)/BD2 Y390A mutant (unknown origin) to IC50 for displacement of Alexa Fluor 647 labelled ligand from 6His-tagged BRD4 BD2 (1 to 477 residue)/BD1 Y97A mutant (unknown origin) | Homo sapiens | 42 | assay format | Scientific Literature | ||
| 4. | ALA4809909 | P | Chromatographic hydrophobicity index, log D of the compound at pH 7.4 by HPLC analysis | 42 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4809910 | P | Solubility of the compound in pH 6.5 FaSSIF at 125 ug/ml measured after 16 hrs by HPLC analysis | 37 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4809911 | A | Permeability of the compound at pH 7.4 by artificial membrane permeability assay | 42 | assay format | Scientific Literature | |||
| 7. | ALA4809912 | F | Inhibition of LPS-induced MCP1 production in human whole blood preincubated for 30 mins followed by LPS addition measured after 24 hrs by immunoassay | Homo sapiens | 11 | tissue-based format | Scientific Literature | ||
| 8. | ALA4809913 | A | Intrinsic clearance in Wistar Han rat cryopreserved pooled hepatocytes at 0.5 uM measured up to 60 mins by LC-MS/MS analysis | Rattus norvegicus | 11 | tissue-based format | Scientific Literature | ||
| 9. | ALA4809914 | A | Intrinsic clearance in Beagle dog cryopreserved pooled hepatocytes at 0.5 uM measured up to 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 11 | tissue-based format | Scientific Literature | ||
| 10. | ALA4809915 | A | Intrinsic clearance in human cryopreserved pooled hepatocytes at 0.5 uM measured up to 120 mins by LC-MS/MS analysis | Homo sapiens | 11 | tissue-based format | Scientific Literature | ||
| 11. | ALA4809916 | A | Clearance in Wistar Han rat at 1 mg/kg, iv administered as 1 hr infusion or 3 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 11 | organism-based format | Scientific Literature | ||
| 12. | ALA4809917 | A | Clearance in Beagle dog at 0.5 mg/kg, iv administered as 1 hr infusion on day 1 and day 7 to achieve a target dose of 1 mg/kg by LC-MS/MS analysis | Canis lupus familiaris | 7 | organism-based format | Scientific Literature | ||
| 13. | ALA4809918 | A | Volume of distribution at steady state in Wistar Han rat at 1 mg/kg, iv administered as 1 hr infusion or 3 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 11 | organism-based format | Scientific Literature | ||
| 14. | ALA4809919 | A | Volume of distribution at steady state in Beagle dog at 0.5 mg/kg, iv administered as 1 hr infusion on day 1 and day 7 to achieve a target dose of 1 mg/kg by LC-MS/MS analysis | Canis lupus familiaris | 7 | organism-based format | Scientific Literature | ||
| 15. | ALA4809920 | A | Oral bioavailability in Wistar Han rat at 3 mg/kg administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 11 | organism-based format | Scientific Literature | ||
| 16. | ALA4809921 | A | Oral bioavailability in Beagle dog | Canis lupus familiaris | 7 | organism-based format | Scientific Literature | ||
| 17. | ALA4809922 | A | Fraction unbound in Wistar Han rat blood measured after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 9 | tissue-based format | Scientific Literature | ||
| 18. | ALA4809923 | A | Fraction unbound in human blood measured after 4 hrs by LC-MS/MS analysis | Homo sapiens | 6 | tissue-based format | Scientific Literature | ||
| 19. | ALA4809924 | A | Fraction unbound in Beagle dog blood measured after 4 hrs by LC-MS/MS analysis | Canis lupus familiaris | 7 | tissue-based format | Scientific Literature | ||
| 20. | ALA4809946 | A | Unbound clearance in Wistar Han rat at 1 mg/kg, iv administered as 1 hr infusion or 3 mg/kg, po administered via gavage by LC-MS/MS analysis | Rattus norvegicus | 10 | organism-based format | Scientific Literature |
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