# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4839297 | Functional | Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization | Homo sapiens | 11 | ALA4837245 | cell-based format | Scientific Literature | |
2. | ALA4839298 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4837245 | microsome format | Scientific Literature | |
3. | ALA4839299 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4837245 | subcellular format | Scientific Literature | |
4. | ALA4839300 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4837245 | microsome format | Scientific Literature | |
5. | ALA4839301 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4837245 | microsome format | Scientific Literature | |
6. | ALA4839302 | ADME | Efflux ratio of apparent permeability basolateral to apical over apical to basolateral side at human P-gp in MDCK-MDR1 cells | Canis lupus familiaris | 12 | ALA4837245 | cell-based format | Scientific Literature | |
7. | ALA4839303 | Functional | Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization | Homo sapiens | 12 | ALA4837245 | cell-based format | Scientific Literature | |
8. | ALA4839304 | Binding | Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization relative to control | Homo sapiens | 12 | ALA4837245 | cell-based format | Scientific Literature | |
9. | ALA4839336 | Binding | Selectivity index, ratio of IC50 for human muscarinic receptor M2 expressed in CHO cells to IC50 for human muscarinic receptor M4 expressed in CHO cells | Homo sapiens | 11 | ALA4837245 | cell-based format | Scientific Literature |