# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4844234 | Binding | Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as suppression of H2O2-induced calcium flux at 30 uM pretreated for 30 mins followed by H2O2 stimulation by Fluo-3/AM assay | Homo sapiens | 46 | ALA4842361 | cell-based format | Scientific Literature | |
2. | ALA4844235 | Binding | Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current at 30 uM by whole cell patch-clamp method relative to control | Homo sapiens | 2 | ALA4842361 | cell-based format | Scientific Literature | |
3. | ALA4844236 | Binding | Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp method | Homo sapiens | 3 | ALA4842361 | cell-based format | Scientific Literature | |
4. | ALA4844237 | Binding | Inhibition of rat TRPM8 expressed in HEK293T cells cotransfected with GFP assessed as inhibition of methanol-induced current at 30 uM by whole cell patch-clamp method relative to control | Rattus norvegicus | 2 | ALA4842361 | cell-based format | Scientific Literature | |
5. | ALA4844238 | Binding | Inhibition of TRPV1 (unknown origin) assessed as inhibition of capsaicin-induced current at 30 uM by whole cell patch-clamp method relative to control | Homo sapiens | 2 | ALA4842361 | single protein format | Scientific Literature | |
6. | ALA4844239 | Binding | Inhibition of lnsP3R in human Jurkat cells assessed as inhibition of histamine-induced increase in calcium level at 30 uM incubated for 30 mins by Fluo-4 dye based fluorescence microscopy | Homo sapiens | 3 | ALA4842361 | cell-based format | Scientific Literature | |
7. | ALA4844240 | Binding | Inhibition of Orai1 in human Jurkat cells assessed as CaCl2-induced increase in calcium level at 30 uM incubated for 30 mins by Fluo-4 dye based fluorescence microscopy | Homo sapiens | 3 | ALA4842361 | cell-based format | Scientific Literature | |
8. | ALA4844241 | Functional | Neuroprotection against H202-induced cell death in human SH-SY5Y cells assessed as increase in cell viability at 100 uM after 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4842361 | cell-based format | Scientific Literature | |
9. | ALA4844242 | Functional | Neuroprotection against H202-induced cell death in TRPM2 knockdown human SH-SY5Y cells assessed as increase in cell viability at 100 uM after 24 hrs by CCK8 assay | Homo sapiens | 2 | ALA4842361 | cell-based format | Scientific Literature | |
10. | ALA4844243 | Functional | Neuroprotection against H202-induced cell death in human SH-SY5Y cells assessed as cell protection at 10 uM after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4842361 | cell-based format | Scientific Literature | |
11. | ALA4844244 | Functional | Neuroprotection against H202-induced cell death in human SH-SY5Y cells assessed as cell protection at 30 uM after 24 hrs by CCK8 assay | Homo sapiens | 3 | ALA4842361 | cell-based format | Scientific Literature | |
12. | ALA4844248 | ADME | Cytotoxicity against human SH-SY5Y cells at 30 uM measured after 24 hrs by CCK-8 assay | Homo sapiens | 2 | ALA4842361 | cell-based format | Scientific Literature |