# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4843602 | ADME | Transactivation of PXR (unknown origin) | Homo sapiens | 13 | ALA4842348 | single protein format | Scientific Literature | |
2. | ALA4843603 | ADME | Transactivation of PXR (unknown origin) at 10 uM relative to control | Homo sapiens | 10 | ALA4842348 | single protein format | Scientific Literature | |
3. | ALA4843604 | Binding | Inhibition of human ERG | Homo sapiens | 3 | ALA4842348 | single protein format | Scientific Literature | |
4. | ALA4843605 | Physicochemical | Solubility of the compound in pH 7 phosphate buffer | 4 | ALA4842348 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4843607 | ADME | Cmax in C57BL/6 mouse at 1 mg/kg, iv and 2 mg/kg, po | Mus musculus | 3 | ALA4842348 | organism-based format | Scientific Literature | |
6. | ALA4843608 | ADME | Dose normalized AUC in C57BL/6 mouse at 2 mg/kg, po | Mus musculus | 4 | ALA4842348 | organism-based format | Scientific Literature | |
7. | ALA4843610 | ADME | Total clearance in C57BL/6 mouse in whole blood at 1 mg/kg, iv | Mus musculus | 3 | ALA4842348 | organism-based format | Scientific Literature | |
8. | ALA4843612 | ADME | Half life in C57BL/6 mouse at 1 mg/kg, iv | Mus musculus | 3 | ALA4842348 | organism-based format | Scientific Literature | |
9. | ALA4843613 | ADME | Oral bioavailability in C57BL/6 mouse at 2 mg/kg | Mus musculus | 4 | ALA4842348 | organism-based format | Scientific Literature | |
10. | ALA4843614 | Functional | Increase in HDL-C in C57BL/6-transgenic mouse expressing human CETP at 10 mg/kg, po bid | Mus musculus | 4 | ALA4842348 | organism-based format | Scientific Literature | |
11. | ALA4843620 | Binding | Inhibition of recombinant CETP (unknown origin) assessed as inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein using exogenous LDL and HDL in 2% human serum by liquid scintillation analysis | Homo sapiens | 10 | ALA4842348 | single protein format | Scientific Literature | |
12. | ALA4843621 | Binding | Inhibition of recombinant CETP (unknown origin) assessed as maximal inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein using exogenous LDL and HDL in 2% human serum at 10 uM measured after 2 hrs by liquid scintillation analysis relative to control | Homo sapiens | 10 | ALA4842348 | single protein format | Scientific Literature |