# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825462 | F | Antibacterial activity against cefoxitin/gentamicin/kanamycin/rifampicin/streptomycin/sulfamethoxazole/tetracycline methicillin-resistant Staphylococcus aureus QA-12.1 assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Staphylococcus aureus | 14 | ALA4823322 | organism-based format | Scientific Literature | |
2. | ALA4825463 | F | Antibacterial activity against cefoxitin/ciprofloxacin/clindamycin/erythromycin/tetracycline/thiamulin/trimethoprim methicillin-resistant Staphylococcus aureus QA-11.7 assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Staphylococcus aureus | 14 | ALA4823322 | organism-based format | Scientific Literature | |
3. | ALA4825464 | B | Inhibition of Escherichia coli DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorimetric assay | Staphylococcus aureus | 14 | ALA4823322 | protein complex format | Scientific Literature | |
4. | ALA4825465 | B | Inhibition of Staphylococcus aureus DNA gyrase assessed as reduction in DNA supercoiling using relaxed pNO1 plasmid DNA as substrate incubated for 30 mins by fluorimetric assay | Staphylococcus aureus | 14 | ALA4823322 | protein complex format | Scientific Literature | |
5. | ALA4825466 | B | Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorimetric assay | Staphylococcus aureus | 14 | ALA4823322 | protein complex format | Scientific Literature | |
6. | ALA4825467 | B | Inhibition of Escherichia coli topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorimetric assay | Escherichia coli | 14 | ALA4823322 | assay format | Scientific Literature | |
7. | ALA4825468 | A | Inhibition of human DNA topoisomerase 2 alpha assessed as enzyme residual activity at 10 uM | Homo sapiens | 14 | ALA4823322 | single protein format | Scientific Literature | |
8. | ALA4825469 | P | Lipophilicity, log D of the compound at pH 7.4 | 14 | ALA4823322 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4825470 | P | Dissociation constant, pKa of the compound at pH 7.4 | 14 | ALA4823322 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4825471 | F | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Staphylococcus aureus | 14 | ALA4823322 | organism-based format | Scientific Literature | |
11. | ALA4825472 | F | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Escherichia coli | 14 | ALA4823322 | organism-based format | Scientific Literature | |
12. | ALA4825473 | F | Antibacterial activity against Escherichia coli D22 harboring lpxC mutant assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Escherichia coli | 14 | ALA4823322 | organism-based format | Scientific Literature | |
13. | ALA4825474 | F | Antibacterial activity against Acra knockout Escherichia coli N43 assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Escherichia coli | 14 | ALA4823322 | organism-based format | Scientific Literature | |
14. | ALA4825475 | F | Antibacterial activity against Klebsiella pneumoniae assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Klebsiella pneumoniae | 14 | ALA4823322 | organism-based format | Scientific Literature | |
15. | ALA4825476 | F | Antibacterial activity against Salmonella alachua RDK 030c (QA-1482/04) assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Salmonella sp. | 14 | ALA4823322 | organism-based format | Scientific Literature | |
16. | ALA4825477 | F | Antibacterial activity against Pseudomonas aeruginosa RDK 184 (DSM939) assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Pseudomonas aeruginosa | 14 | ALA4823322 | organism-based format | Scientific Literature | |
17. | ALA4825478 | F | Antibacterial activity against Streptococcus agalactiae RDK 047 (QA-990/02) assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Streptococcus agalactiae | 14 | ALA4823322 | organism-based format | Scientific Literature | |
18. | ALA4825479 | F | Antibacterial activity against Enterococcus faecalis ATCC 29212 (DRK057) assessed as bacterial growth inhibition and measured after 20 hrs by CLSI-based broth microdilution assay | Enterococcus faecalis | 14 | ALA4823322 | organism-based format | Scientific Literature | |
19. | ALA4825482 | A | Cytotoxicity against human HUVEC cells assessed as reduction in cell proliferation measured after 72 hrs by CellTiter96 Aqueous One Solution Cell Proliferation Assay | Homo sapiens | 8 | ALA4823322 | cell-based format | Scientific Literature | |
20. | ALA4825483 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by CellTiter96 Aqueous One Solution Cell Proliferation Assay | Homo sapiens | 8 | ALA4823322 | cell-based format | Scientific Literature |