# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4829859 | Binding | Inhibition of human recombinant Cathepsin C using H-Gly-Arg-AMC as substrate pretreated for 30 mins followed by substrate addition incubated for 60 mins | Homo sapiens | 74 | ALA4828733 | single protein format | Scientific Literature | |
2. | ALA4829860 | Binding | Inhibition of human Cathepsin C in human THP-1 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated for 60 mins | Homo sapiens | 74 | ALA4828733 | cell-based format | Scientific Literature | |
3. | ALA4829861 | Binding | Inhibition of human Cathepsin C in human U-937 cells using H-Gly-Phe-AFC as substrate pretreated for 60 mins followed by substrate addition incubated for 60 mins | Homo sapiens | 74 | ALA4828733 | cell-based format | Scientific Literature | |
4. | ALA4829862 | ADME | Cytotoxicity against human L02 cells assessed as cell viability incubated for 48 hrs by CCK-8 assay | Homo sapiens | 74 | ALA4828733 | cell-based format | Scientific Literature | |
5. | ALA4829863 | ADME | Intrinsic clearance in mouse liver microsomes measured up to 120 mins by LC-MS/MS analysis | Mus musculus | 16 | ALA4828733 | microsome format | Scientific Literature | |
6. | ALA4829864 | ADME | Intrinsic clearance in human liver microsomes measured up to 120 mins by LC-MS/MS analysis | Homo sapiens | 16 | ALA4828733 | microsome format | Scientific Literature | |
7. | ALA4829865 | Physicochemical | Solubility of the compound in water | 16 | ALA4828733 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4829866 | Physicochemical | Solubility of the compound in PBS buffer | 16 | ALA4828733 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4829867 | Physicochemical | Solubility of the compound in artificial gastric juice | 16 | ALA4828733 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4829868 | Physicochemical | Solubility of the compound in artificial intestinal juice | 16 | ALA4828733 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4829869 | Physicochemical | Octanol/water partition coefficient, logP of compound at pH 7.4 | 16 | ALA4828733 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4829870 | Binding | Inhibition of Cathepsin B (unknown origin) using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mins | Homo sapiens | 4 | ALA4828733 | single protein format | Scientific Literature | |
13. | ALA4829871 | Binding | Inhibition of Cathepsin L (unknown origin) using Z-Leu-Arg-AMC as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mins | Homo sapiens | 4 | ALA4828733 | single protein format | Scientific Literature | |
14. | ALA4829872 | Binding | Inhibition of Cathepsin S (unknown origin) using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mins | Homo sapiens | 4 | ALA4828733 | single protein format | Scientific Literature | |
15. | ALA4829873 | Binding | Inhibition of Cathepsin K (unknown origin) using MCA-Arg-Pro-Lys-Pro-Val-Glu-NVAL-Trp-Arg-Lys-(DNP)-NH2 as substrate pretreated for 60 mins followed by substrate addition incubated for 30 mins | Homo sapiens | 4 | ALA4828733 | single protein format | Scientific Literature | |
16. | ALA4829891 | Binding | Binding affinity to Cathepsin C in human THP-1 cells assessed as thermal stability measured at 10 uM incubated for 3 to 5 hrs by cellular thermal shift assay (Rvb = 49 degC) | Homo sapiens | 4 | ALA4828733 | cell-based format | Scientific Literature | |
17. | ALA4829892 | Binding | Binding affinity to Cathepsin C in human THP-1 cells assessed as increase in thermal stability measured at 52 degC incubated for 3 to 5 hrs by cellular thermal shift assay | Homo sapiens | 2 | ALA4828733 | cell-based format | Scientific Literature |