# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831759 | Functional | Antileishmanial activity against Leishmania donovani axenic amastigotes at 10 ug/mL assessed as growth inhibition relative to control | Leishmania donovani | 1 | ALA4831481 | organism-based format | Scientific Literature | |
2. | ALA4831760 | Functional | Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in African green monkey Vero cells incubated for 5 days at 10 ug/mL by chlorophenol red-beta-D-galactoside based colorimetric analysis relative to control | Trypanosoma cruzi | 1 | ALA4831481 | organism-based format | Scientific Literature | |
3. | ALA4831761 | Functional | Growth inhibition of human MCF7 cells at 10 ug/mL relative to control | Homo sapiens | 1 | ALA4831481 | cell-based format | Scientific Literature | |
4. | ALA4831762 | Functional | Antiplasmodial activity against Plasmodium falciparum HB3 infected in human erythrocytes assessed as reduction in parasite growth incubated for 48 hrs by PicoGreen DNA fluorescent dye | Plasmodium falciparum | 5 | ALA4831481 | organism-based format | Scientific Literature | |
5. | ALA4831763 | Functional | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay | Chlorocebus sabaeus | 5 | ALA4831481 | cell-based format | Scientific Literature | |
6. | ALA4831764 | Toxicity | Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Plasmodium falciparum HB3 infected in human erythrocytes assessed as reduction in parasite growth | 5 | ALA4831481 | cell-based format | Scientific Literature | ||
7. | ALA4831765 | Binding | Disruption of cell membrane integrity in schizont stage Plasmodium falciparum HB3 infected red blood cells incubated for 3 hrs at 10 uM and measured by propidium iodide incorporation assay relative to control | Plasmodium falciparum HB3 | 1 | ALA4831481 | cell membrane format | Scientific Literature | |
8. | ALA4831766 | ADME | Disruption of cell membrane integrity in red blood cells incubated for 3 hrs at 10 uM and measured by propidium iodide incorporation assay relative to control | Not specified | 1 | ALA4831481 | cell membrane format | Scientific Literature | |
9. | ALA4831767 | ADME | Hemolytic activity against red blood cells assessed as hemolysis at 10 uM incubated for 24 hrs by spectrophotometric analysis relative to control | 1 | ALA4831481 | cell-based format | Scientific Literature | ||
10. | ALA4831768 | Functional | Antiapoptotic activity in schizont stage Plasmodium falciparum HB3 assessed as reduction in mitochondrial membrane potential at 10 uM incubated for 20 mins and measured after 3 hrs by DiOC6-staining based fluorometry analysis relative to control | Plasmodium falciparum | 1 | ALA4831481 | organism-based format | Scientific Literature | |
11. | ALA4831769 | Functional | Induction of reactive oxygen species generation in schizont stage Plasmodium falciparum HB3 incubated for 3 hrs at 10 uM by CM-H2DCFDA dye based fluorescence assay relative to control | Plasmodium falciparum | 1 | ALA4831481 | organism-based format | Scientific Literature | |
12. | ALA4831770 | Functional | Induction of apoptosis in schizont stage Plasmodium falciparum HB3 infected red blood cells assessed as caspase activity measured by FLICA reagent based fluorescence assay | Plasmodium falciparum | 1 | ALA4831481 | organism-based format | Scientific Literature | |
13. | ALA4831771 | Binding | Inhibition of beta-hematin formation in Plasmodium falciparum assessed as decrease in beta-hematin | Plasmodium falciparum | 2 | ALA4831481 | assay format | Scientific Literature | |
14. | ALA4831772 | Binding | Inhibition of Escherichia coli DNA gyrase at 10 uM by fluorescence based assay relative to control | Escherichia coli | 1 | ALA4831481 | protein complex format | Scientific Literature |