# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4827844 | Binding | Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide incubated for 2 hrs by TR-FRET assay | Homo sapiens | 52 | ALA4825732 | single protein format | Scientific Literature | |
2. | ALA4827845 | Binding | Inhibition of PKA-delta (unknown origin) using Fam-labelled S6-derived peptide incubated for 2 hrs by TR-FRET assay | Homo sapiens | 50 | ALA4825732 | single protein format | Scientific Literature | |
3. | ALA4827847 | ADME | Stability in rat liver S9 fraction assessed as compound remaining after 1 hr | Rattus norvegicus | 31 | ALA4825732 | subcellular format | Scientific Literature | |
4. | ALA4827848 | ADME | Stability in human liver S9 fraction assessed as compound remaining after 1 hr | Homo sapiens | 31 | ALA4825732 | subcellular format | Scientific Literature | |
5. | ALA4827849 | ADME | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 3 | ALA4825732 | cell-based format | Scientific Literature | |
6. | ALA4827850 | ADME | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 3 | ALA4825732 | cell-based format | Scientific Literature | |
7. | ALA4827851 | Binding | Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide at 3 uM incubated for 2 hrs by TR-FRET assay relative to control | Homo sapiens | 3 | ALA4825732 | single protein format | Scientific Literature | |
8. | ALA4827856 | ADME | Oral bioavailability in mouse at 10 mg/kg | Mus musculus | 1 | ALA4825732 | organism-based format | Scientific Literature | |
9. | ALA4827857 | ADME | Oral bioavailability in rat at 10 mg/kg | Rattus norvegicus | 1 | ALA4825732 | organism-based format | Scientific Literature | |
10. | ALA4827858 | ADME | Oral bioavailability in dog at 10 mg/kg | Canis lupus familiaris | 1 | ALA4825732 | organism-based format | Scientific Literature | |
11. | ALA4827859 | ADME | Inhibition of CYP2C9 in human liver microsome | Homo sapiens | 1 | ALA4825732 | microsome format | Scientific Literature | |
12. | ALA4827860 | ADME | Inhibition of CYP2C19 in human liver microsome | Homo sapiens | 1 | ALA4825732 | microsome format | Scientific Literature | |
13. | ALA4827861 | Binding | Inhibition of human ERG | Homo sapiens | 1 | ALA4825732 | single protein format | Scientific Literature | |
14. | ALA4827862 | Binding | Inhibition of histamine H1 receptor (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | ALA4825732 | single protein format | Scientific Literature | |
15. | ALA4827863 | Binding | Inhibition of histamine H1 receptor (unknown origin) | Homo sapiens | 1 | ALA4825732 | single protein format | Scientific Literature | |
16. | ALA4827864 | Binding | Inhibition of PKC-theta in PBMC isolated from human leukocyte reduction system white blood cells isolated assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrs | Homo sapiens | 1 | ALA4825732 | tissue-based format | Scientific Literature | |
17. | ALA4827865 | Binding | Inhibition of PKC-theta in PBMC isolated from human leukocyte whole blood assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrs | Homo sapiens | 1 | ALA4825732 | tissue-based format | Scientific Literature | |
18. | ALA4827866 | Binding | Inhibition of PKC-theta in human whole blood assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrs | Homo sapiens | 1 | ALA4825732 | tissue-based format | Scientific Literature | |
19. | ALA4827867 | Binding | Inhibition of PKC-theta in human mixed lymphocyte reaction assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrs | Homo sapiens | 1 | ALA4825732 | tissue-based format | Scientific Literature | |
20. | ALA4827868 | Binding | Inhibition of PKC-theta in mouse whole blood assessed as reduction in anti-CD3/CD28-stimulated IL-2 expression measured for 20 hrs | Mus musculus | 1 | ALA4825732 | tissue-based format | Scientific Literature |