# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4841524 | B | Inhibition of COL1A1 promotor activity in human LX2 cells at 20 uM incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
2. | ALA4841525 | B | Inhibition of COL1A1 promotor activity in human LX2 cells at 50 uM incubated for 24 hrs by luciferase reporter gene assay | Homo sapiens | 61 | cell-based format | Scientific Literature | ||
3. | ALA4841526 | A | Cytotoxicity against human LX2 cells assessed as cell death incubated for 24 hrs by MTT assay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
4. | ALA4841527 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced COL1A1 mRNA expression at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
5. | ALA4841528 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced ACTA2 mRNA expression at 3 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4841529 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced CTGF mRNA expression at 3 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4841530 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced ACTA2 mRNA expression at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4841531 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced MMP2 mRNA expression at 3 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4841532 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced MMP2 mRNA expression at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4841533 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced CTGF mRNA expression at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4841534 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced TGFbeta1 mRNA expression at 3 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4841535 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced TGFbeta1 mRNA expression at 10 uM incubated for 24 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4841536 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced COL1A1 protein level at 3 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA4841537 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced MMP2 protein level at 3 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA4841538 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced CTGF protein level at 3 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA4841539 | F | Anti-fibrogenic activity in human LX2 cells assessed as inhibition of TGFbeta1-induced TGFbeta1 protein level at 3 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA4841540 | B | Inhibition of TGF-beta1 induced SMAD2/3 phosphorylation in human LX2 cells at 3 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA4841541 | B | Inhibition of TGF-beta1 induced SMAD3 phosphorylation in human LX2 cells by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA4841542 | F | Down regulation of PI3K expression in TGF-beta1 induced human LX2 cells after 24 hrs by Western blot analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
20. | ALA4841543 | B | Inhibition of PI3K/Akt pathway in human LX2 cells assessed as inhibition of TGF-beta1 induced AKT phosphorylation at 3 to 10 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |