# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4828599 | Binding | Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated with KRAS for 5 mins followed by incubation with SOS (564 to 1049 residues) and GTP for 30 mins and later incubated with GST-tagged cRAF (1 to 149 residues) for 10 mins by AlphaLISA assay | Homo sapiens | 11 | ALA4825768 | single protein format | Scientific Literature | |
2. | ALA4828600 | Binding | Inhibition of GDP-bound KRAS G12C mutant (1 to 169 residues) (unknown origin) assessed as inhibition of SOS-mediated nucleotide exchange pretreated with KRAS for 20 hrs followed by incubation with SOS (564 to 1049 residues) and GTP for 30 mins and later incubated with GST-tagged cRAF (1 to 149 residues) for 10 mins by AlphaLISA assay | Homo sapiens | 11 | ALA4825768 | single protein format | Scientific Literature | |
3. | ALA4828601 | Binding | Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in phosphorylated ERK1/2 level incubated for 2 hrs by MSD assay | Homo sapiens | 11 | ALA4825768 | cell-based format | Scientific Literature | |
4. | ALA4828602 | Binding | Binding affinity to GDP-bound KRAS G12D mutant (unknown origin) assessed as bound fraction at 100 uM incubated for 20 hrs by RF-MS analysis relative to control | Homo sapiens | 11 | ALA4825768 | single protein format | Scientific Literature |