# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4838295 | F | Down regulation of precursor and mature forms of SREBP-2 protein expression in human HepG2 cells after 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
2. | ALA4838296 | B | Induction of SREBP degradation in human HepG2 cells at 10 uM preincubated with cycloheximide for 1 hr followed by compound additon by Western blot analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
3. | ALA4838297 | F | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 10 uM after 24 hrs by CCK8 assay | Homo sapiens | 48 | ALA4837214 | cell-based format | Scientific Literature | |
4. | ALA4838298 | F | Down regulation of intracellular TC level in human HepG2 cells at 10 uM measured after 24 hrs | Homo sapiens | 5 | ALA4837214 | cell-based format | Scientific Literature | |
5. | ALA4838299 | F | Down regulation of intracellular TG level in human HepG2 cells at 10 uM measured after 24 hrs | Homo sapiens | 6 | ALA4837214 | cell-based format | Scientific Literature | |
6. | ALA4838300 | T | Toxicity in high fat diet-induced C57BL/6J mouse assessed as reduction in body weight at 170 to 340 mg/kg, po measured every week for 6 weeks | Mus musculus | 1 | ALA4837214 | organism-based format | Scientific Literature | |
7. | ALA4838301 | T | Toxicity in C57BL/6J mouse assessed as reduction in liver weight at 170 to 340 mg/kg, po measured every week for 6 weeks | Mus musculus | 1 | ALA4837214 | organism-based format | Scientific Literature | |
8. | ALA4838302 | F | Down regulation of precursor and mature forms of SREBP-1 protein expression in human HepG2 cells after 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
9. | ALA4838303 | F | Effect on PCSK9 protein expression in human HepG2 cells at 10 uM incubated for 24 hrs by Western blotting analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
10. | ALA4838304 | F | Down regulation of ACC gene expression in human HepG2 cells by qRT-PCR analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
11. | ALA4838305 | F | Down regulation of FASN gene expression in human HepG2 cells by qRT-PCR analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
12. | ALA4838306 | F | Down regulation of LDLR gene expression in human HepG2 cells by qRT-PCR analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
13. | ALA4838307 | F | Down regulation of SCD gene expression in human HepG2 cells by qRT-PCR analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
14. | ALA4838308 | B | Induction of SREBP degradation in human HepG2 cells at 10 uM preincubated with MG-132 for 1 hr followed by compound additon and measured after 4 hrs by Western blot analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
15. | ALA4838309 | B | Induction of SREBP degradation expressed in human HEK293T cells assessed as increase in SREBP ubiquitination at 10 uM after 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4837214 | cell-based format | Scientific Literature | |
16. | ALA4838310 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4837214 | organism-based format | Scientific Literature | |
17. | ALA4838311 | A | Cmax in Sprague-Dawley rat at 1 mg/kg, iv measured upto 12 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4837214 | organism-based format | Scientific Literature | |
18. | ALA4838312 | A | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4837214 | organism-based format | Scientific Literature | |
19. | ALA4838313 | A | AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv measured upto 12 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4837214 | organism-based format | Scientific Literature | |
20. | ALA4838314 | A | MRT (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4837214 | organism-based format | Scientific Literature |