# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835450 | B | Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
2. | ALA4835451 | B | Selectivity ratio of IC50 for N-terminal His6-tagged recombinant full length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells to IC50 for N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
3. | ALA4835452 | B | Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated for 20 mins followed by anti-IgM antibody stimulation and measured after 30 mins by alphascreen assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
4. | ALA4835453 | B | Inhibition of adenosine transporter in human HeLa cells assessed as reduction in [3H]adenosine uptake preincubated for 30 mins followed by [3H]adenosine addition and measured after 60 mins | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
5. | ALA4835456 | P | Lipophilicity, log D of the compound by HPLC analysis | 24 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4835459 | A | Volume of distribution in Wistar Han rat | Rattus norvegicus | 24 | assay format | Scientific Literature | ||
7. | ALA4835460 | A | Unbound volume of distribution in Wistar Han rat | Rattus norvegicus | 24 | assay format | Scientific Literature | ||
8. | ALA4835461 | A | Half-life in Wistar Han rat | Rattus norvegicus | 24 | assay format | Scientific Literature | ||
9. | ALA4835463 | A | Plasma clearance in Beagle dog at 0.05 mg/kg | Canis lupus familiaris | 8 | organism-based format | Scientific Literature | ||
10. | ALA4835464 | A | Intrinsic clearance in Beagle dog at 0.05 mg/kg | Canis lupus familiaris | 8 | organism-based format | Scientific Literature | ||
11. | ALA4835467 | A | Volume of distribution in Beagle dog | Canis lupus familiaris | 19 | assay format | Scientific Literature | ||
12. | ALA4835468 | A | Unbound volume of distribution in Beagle dog | Canis lupus familiaris | 19 | assay format | Scientific Literature | ||
13. | ALA4835469 | A | Half-life in Beagle dog | Canis lupus familiaris | 19 | assay format | Scientific Literature | ||
14. | ALA4835522 | A | Plasma clearance in Wistar Han rat at 0.05 mg/kg, iv or 1 mg/kg, po | Rattus norvegicus | 8 | organism-based format | Scientific Literature | ||
15. | ALA4835523 | A | Intrinsic clearance in Wistar Han rat at 0.05 mg/kg, iv or 1 mg/kg, po | Rattus norvegicus | 8 | organism-based format | Scientific Literature |