| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4831679 | F | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as bacterial growth inhibition incubated for 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 46 | organism-based format | Scientific Literature | ||
| 2. | ALA4831680 | A | Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Chlorocebus sabaeus | 29 | cell-based format | Scientific Literature | ||
| 3. | ALA4831681 | T | Selectivity index, ratio of IC50 for African green monkey Vero cells to MIC for antitubercular activity against Mycobacterium tuberculosis H37Rv | 29 | assay format | Scientific Literature | |||
| 4. | ALA4831682 | B | Non-covalent inhibition of DprE1 in Mycobacterium tuberculosis H37Rv measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis H37Rv | 12 | single protein format | Scientific Literature | ||
| 5. | ALA4831683 | B | Non-covalent inhibition of DprE1 in multidrug-resistant Mycobacterium tuberculosis clinical isolate 13946 measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 10 | assay format | Scientific Literature | ||
| 6. | ALA4831684 | B | Non-covalent inhibition of DprE1 in multidrug-resistant Mycobacterium tuberculosis clinical isolate 14862 measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 10 | assay format | Scientific Literature | ||
| 7. | ALA4831685 | B | Non-covalent inhibition of DprE1 in PBTZ169-resistant Mycobacterium tuberculosis measured after 7 days by microplate Alamar blue assay | Mycobacterium tuberculosis | 5 | assay format | Scientific Literature | ||
| 8. | ALA4831687 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as reduction in bacterial colony forming units at 10 ug/ml incubated for 3 days (Rvb = 5.52 +/- 0.18 log10CFU) | Mycobacterium tuberculosis | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA4831688 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as change in bacterial colony forming units at 10 ug/ml incubated for 3 days | Mycobacterium tuberculosis | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA4831689 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as reduction in bacterial colony forming units at 5 ug/ml incubated for 3 days (Rvb = 5.52 +/- 0.18 log10CFU) | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
| 11. | ALA4831690 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse J774.1 cells assessed as change in bacterial colony forming units at 5 ug/ml incubated for 3 days | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
| 12. | ALA4831691 | A | Half life in mouse hepatocytes at 1 uM by LC-MS/MS analysis | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA4831692 | A | Stability in mouse hepatocytes assessed as parent compound remaining at 1 uM measured after 30 mins by LC-MS/MS analysis | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA4831693 | A | Half life in human hepatocytes at 1 uM by LC-MS/MS analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 15. | ALA4831694 | A | Stability in human hepatocytes assessed as parent compound remaining at 1 uM measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 16. | ALA4831695 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 17. | ALA4831696 | B | Inhibition of human ERG | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 18. | ALA4831714 | F | Antibacterial activity against Mycobacterium bovis BCG transfected with pMV261:Mt-dprE1 assessed as bacterial growth inhibition incubated for 7 days by resazurin assay | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
| 19. | ALA4831715 | F | Antibacterial activity against Mycobacterium bovis BCG transfected with pMV261:Mt-dprE2 assessed as bacterial growth inhibition incubated for 7 days by resazurin assay | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature | ||
| 20. | ALA4831716 | F | Antibacterial activity against wild type Mycobacterium bovis BCG assessed as bacterial growth inhibition incubated for 7 days by resazurin assay | Mycobacterium tuberculosis | 7 | organism-based format | Scientific Literature |
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