# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4840117 | Binding | Inhibition of JNK3alpha1 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 31 | ALA4837263 | single protein format | Scientific Literature | |
2. | ALA4840118 | Binding | Inhibition of JNK1 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 29 | ALA4837263 | single protein format | Scientific Literature | |
3. | ALA4840119 | Binding | Inhibition of JNK2 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 29 | ALA4837263 | single protein format | Scientific Literature | |
4. | ALA4840120 | Binding | Inhibition of p38 alpha (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis | Homo sapiens | 29 | ALA4837263 | single protein format | Scientific Literature | |
5. | ALA4840121 | Binding | Selectivity index, ratio of IC50 for JNK1 (unknown origin) to IC50 for JNK3 (unknown origin) | 25 | ALA4837263 | assay format | Scientific Literature | ||
6. | ALA4840122 | Binding | Selectivity index, ratio of IC50 for JNK2 (unknown origin) to IC50 for JNK3 (unknown origin) | 10 | ALA4837263 | assay format | Scientific Literature | ||
7. | ALA4840123 | Binding | Selectivity index, ratio of IC50 for p38 alpha (unknown origin) to IC50 for JNK3 (unknown origin) | 25 | ALA4837263 | assay format | Scientific Literature | ||
8. | ALA4840124 | Binding | Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological method | Homo sapiens | 11 | ALA4837263 | cell-based format | Scientific Literature | |
9. | ALA4840125 | ADME | Inhibition of CYP1A2 (unknown origin) assessed as phenaceten demethylation to acetaminophen at 10 uM by cocktail inhibition assay relative to control | Homo sapiens | 9 | ALA4837263 | single protein format | Scientific Literature | |
10. | ALA4840126 | ADME | Inhibition of CYP2C9 (unknown origin) assessed as tolbutamide hydroxylation to hydrocytolbutamide at 10 uM by cocktail inhibition assay relative to control | Homo sapiens | 9 | ALA4837263 | single protein format | Scientific Literature | |
11. | ALA4840127 | ADME | Inhibition of CYP2D6 (unknown origin) assessed as bufuralol hydroxylation to 4'-hydroxy bufuralol at 10 uM by cocktail inhibition assay relative to control | Homo sapiens | 9 | ALA4837263 | single protein format | Scientific Literature | |
12. | ALA4840128 | ADME | Inhibition of CYP3A4 (unknown origin) assessed as midazolam hydroxylation to 1'-hydroxy midazolam at 10 uM by cocktail inhibition assay relative to control | Homo sapiens | 9 | ALA4837263 | single protein format | Scientific Literature | |
13. | ALA4840131 | ADME | Stability in human liver microsome assessed as half life | Homo sapiens | 9 | ALA4837263 | microsome format | Scientific Literature | |
14. | ALA4840132 | ADME | Stability in mouse liver microsome assessed as half life | Mus musculus | 9 | ALA4837263 | microsome format | Scientific Literature | |
15. | ALA4840133 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability at 10 uM measured after 48 hrs by MTT assay | Homo sapiens | 9 | ALA4837263 | cell-based format | Scientific Literature | |
16. | ALA4840144 | Binding | Inhibition of JNK3 in rat primary neuron assessed as reduction in phosphorylation of APP at T688 residue at < 1 nM incubated for 30 mins by Western blot analysis | Rattus norvegicus | 2 | ALA4837263 | cell-based format | Scientific Literature |