# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4818574 | Binding | Inhibition of recombinant full length 6His-tagged PARP1 (unknown origin) incubated for 4 hrs by fluorescence anisotropy assay | Homo sapiens | 6 | ALA4814061 | single protein format | Scientific Literature | |
2. | ALA5152028 | Binding | Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluorescence anisotropy binding assay | Homo sapiens | 25 | ALA5150005 | assay format | Scientific Literature | |
3. | ALA5152029 | Binding | Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluorescence anisotropy binding assay | Homo sapiens | 25 | ALA5150005 | assay format | Scientific Literature | |
4. | ALA5152030 | Binding | Selectivity ratio of IC50 for PARP1 (unknown origin) to IC50 for PARP2 (unknown origin ) | Homo sapiens | 25 | ALA5150005 | assay format | Scientific Literature | |
5. | ALA5152032 | Functional | Antiproliferative activity against human DLD-1 deficient in BRCA-2 cells measured after 7 days | Homo sapiens | 21 | ALA5150005 | cell-based format | Scientific Literature | |
6. | ALA5152033 | Toxicity | Inhibition of human ERG | Homo sapiens | 19 | ALA5150005 | assay format | Scientific Literature | |
7. | ALA5152034 | Physicochemical | Aqueous solubility of the compound at pH 7.4 | 19 | ALA5150005 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5152035 | Physicochemical | Lipophilicity, logD of compound at pH 7.4 | 19 | ALA5150005 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA5152036 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 19 | ALA5150005 | microsome format | Scientific Literature | |
10. | ALA5152037 | ADME | Efflux ratio in human Caco-2 cells at pH 7.4 | Homo sapiens | 14 | ALA5150005 | cell-based format | Scientific Literature | |
11. | ALA5152038 | ADME | Intrinsic clearance in human hepatocytes measured per million of cells | Homo sapiens | 3 | ALA5150005 | cell-based format | Scientific Literature |