# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4813902 | Binding | Inhibition of recombinant GGDPS (unknown origin) using FPP and [14C] IPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by liquid scintillation counting method | Homo sapiens | 10 | ALA4811322 | single protein format | Scientific Literature | |
2. | ALA4813903 | Binding | Inhibition of GGDPS in human RPMI-8226 cells assessed as lowest effective concentration required to show unmodified Rap1a band after 48 hrs by immunoblot analysis | Homo sapiens | 8 | ALA4811322 | cell-based format | Scientific Literature | |
3. | ALA4813906 | Binding | Inhibition of GGDPS in human RPMI-8226 cells assessed as disruption of farnesylation at 0.1 to 1 uM measured after 48 hrs by immunoblot analysis | Homo sapiens | 3 | ALA4811322 | cell-based format | Scientific Literature | |
4. | ALA4813908 | Functional | Cytotoxicity against human RPMI-8226 cells assessed as decrease in cell viability at 10 to 100 uM measured after 48 hrs by MTT assay | Homo sapiens | 7 | ALA4811322 | cell-based format | Scientific Literature |