| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4821630 | Functional | Cytotoxicity against human HL-60 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 19 | ALA4819079 | cell-based format | Scientific Literature | |
| 2. | ALA4821631 | Functional | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 19 | ALA4819079 | cell-based format | Scientific Literature | |
| 3. | ALA4821632 | ADME | Cytotoxicity against human HUVEC cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 19 | ALA4819079 | cell-based format | Scientific Literature | |
| 4. | ALA4821633 | ADME | Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 10 | ALA4819079 | cell-based format | Scientific Literature | |
| 5. | ALA4821634 | Toxicity | Selectivity index, ratio of IC50 for human HUVEC cells to IC50 for human HL-60 cells by MTT assay | Homo sapiens | 19 | ALA4819079 | assay format | Scientific Literature | |
| 6. | ALA4821635 | Toxicity | Selectivity index, ratio of IC50 for human MCF-10A cells to IC50 for human MCF7 cells by MTT assay | Homo sapiens | 10 | ALA4819079 | assay format | Scientific Literature | |
| 7. | ALA4821636 | Functional | Cytotoxicity against human HL-60 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 8. | ALA4821637 | Functional | Induction of cell cycle arrest in human HL-60 cells assessed as accumulation of cells at S phase at IC50 incubated for 24 hrs by DAPI staining based flow cytometric analysis | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 9. | ALA4821638 | Functional | Induction of cell cycle arrest in human HL-60 cells assessed as accumulation of cells at S phase at 2 times IC50 incubated for 24 hrs by DAPI staining based flow cytometric analysis | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 10. | ALA4821640 | Functional | Induction of cell cycle arrest in human HL-60 cells assessed as accumulation of cells at subG0/G1 phase at IC50 incubated for 24 hrs by DAPI staining based flow cytometric analysis | Homo sapiens | 1 | ALA4819079 | cell-based format | Scientific Literature | |
| 11. | ALA4821641 | Functional | Induction of cell cycle arrest in human HL-60 cells assessed as accumulation of cells at subG0/G1 phase at 2 times IC50 incubated for 24 hrs by DAPI staining based flow cytometric analysis | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 12. | ALA4821643 | Functional | Inhibition of DNA synthesis in human HL-60 cells assessed as reduction in cell proliferating cells at IC50 measured after 24 by by BrdU incorporation assay (Rvb = 86 +/- 0.01%) | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 13. | ALA4821645 | Functional | Inhibition of DNA synthesis in human HL-60 cells assessed as reduction in cell proliferating cells at 4 times IC50 measured after 24 by by BrdU incorporation assay (Rvb = 86 +/- 0.01%) | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 14. | ALA4821646 | Functional | Induction of apoptosis in human HL-60 cells assessed as increase in cleaved PARP level at IC50 after 24 hrs by Western blot analysis (Rvb = 2.1 +/- 0.4%) | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 15. | ALA4821647 | Functional | Induction of apoptosis in human HL-60 cells assessed as increase in cleaved PARP level at 2 times IC50 after 24 hrs by Western blot analysis (Rvb = 2.1 +/- 0.4%) | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 16. | ALA4821650 | Functional | Induction of apoptosis in human HL-60 cells assessed as late apoptotic cells at 1.5 times IC50 after 24 hrs by Annexin-V/PI-staining based flow cytometry (Rvb = 6.1+/-0.1%) | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 17. | ALA4821651 | Functional | Induction of apoptosis in human HL-60 cells assessed as late apoptotic cells at 2 times IC50 after 24 hrs by Annexin-V/PI-staining based flow cytometry (Rvb = 6.1+/-0.1%) | Homo sapiens | 2 | ALA4819079 | cell-based format | Scientific Literature | |
| 18. | ALA4821652 | Functional | Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at IC50 after 24 hrs by Annexin-V/PI-staining based flow cytometry (Rvb = 2.5+/-0.1%) | Homo sapiens | 1 | ALA4819079 | cell-based format | Scientific Literature | |
| 19. | ALA4821653 | Functional | Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at 1.5 times IC50 after 24 hrs by Annexin-V/PI-staining based flow cytometry (Rvb = 2.5+/-0.1%) | Homo sapiens | 1 | ALA4819079 | cell-based format | Scientific Literature | |
| 20. | ALA4821654 | Functional | Induction of apoptosis in human HL-60 cells assessed as early apoptotic cells at 2 times IC50 after 24 hrs by Annexin-V/PI-staining based flow cytometry (Rvb = 2.5+/-0.1%) | Homo sapiens | 1 | ALA4819079 | cell-based format | Scientific Literature |
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