# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4837920 | Binding | Inhibition of wild type HIV1 protease using Arg-Glu (EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrate preincubated for 20 to 30 mins followed by substrate addition and measured for 10 mins by FRET assay | Human immunodeficiency virus 1 | 22 | ALA4837199 | single protein format | Scientific Literature | |
2. | ALA4837921 | Functional | Antiviral activity against HIV1 | Human immunodeficiency virus 1 | 22 | ALA4837199 | organism-based format | Scientific Literature | |
3. | ALA4837922 | ADME | Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 22 | ALA4837199 | cell-based format | Scientific Literature | |
4. | ALA4837924 | Functional | Antiviral activity against HIV1 Env-deficient VSV-G pseudotyped virus infected in human SUP-T1 cells infected with supernatant of compound treated virus-producing 293T cells assessed as inhibition of late stage viral production at 10 uM treated for 48 hrs with virus-producing 293T cells followed by SUP-T1 cells infection for 48 hrs by single-round infection luciferase assay relative to control | Human immunodeficiency virus 1 | 9 | ALA4837199 | organism-based format | Scientific Literature |