# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831807 | Binding | Inhibition of CDK8/Cyclin C (unknown origin) at 10 uM measured after 1 hr by plate reader assay relative to control | Homo sapiens | 53 | ALA4831484 | protein complex format | Scientific Literature | |
2. | ALA4831808 | Functional | Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 53 | ALA4831484 | cell-based format | Scientific Literature | |
3. | ALA4831809 | Binding | Inhibition of CDK8/Cyclin C (unknown origin) measured after 1 hr by plate reader assay | Homo sapiens | 54 | ALA4831484 | protein complex format | Scientific Literature | |
4. | ALA4831810 | Functional | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay | Homo sapiens | 28 | ALA4831484 | cell-based format | Scientific Literature | |
5. | ALA4831811 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay | Homo sapiens | 28 | ALA4831484 | cell-based format | Scientific Literature | |
6. | ALA4831812 | Functional | Antiproliferative activity against human KB cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay | Homo sapiens | 28 | ALA4831484 | cell-based format | Scientific Literature | |
7. | ALA4831813 | Functional | Antiproliferative activity against human KB-VIN cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay | Homo sapiens | 28 | ALA4831484 | cell-based format | Scientific Literature | |
8. | ALA4831814 | Functional | Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay | Homo sapiens | 28 | ALA4831484 | cell-based format | Scientific Literature | |
9. | ALA4831819 | Toxicity | Toxicity in BALB/c mouse xenografted with human HCT-116 cells assessed as mortality at 150 mg/kg, po measured after 14 days | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature | |
10. | ALA4831820 | Toxicity | Toxicity in BALB/c mouse xenografted with human HCT-116 cells assessed as changes in body weight at 150 mg/kg, po measured after 14 days | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature | |
11. | ALA4831821 | Functional | Antitumour activity against human HCT-116 cells assessed as decrease in tumor volume at 150 mg/kg, po measured after 14 days relative to control | Homo sapiens | 1 | ALA4831484 | organism-based format | Scientific Literature | |
12. | ALA4831822 | ADME | AUC (0 to 24h) in ICR mouse at 150 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature | |
13. | ALA4831823 | ADME | MRT (0 to 24h) in ICR mouse at 150 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature | |
14. | ALA4831824 | ADME | Half-life in ICR mouse at 150 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature | |
15. | ALA4831825 | ADME | Tmax in ICR mouse at 150 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature | |
16. | ALA4831826 | ADME | Cmax in ICR mouse at 150 mg/kg, po measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4831484 | organism-based format | Scientific Literature |