# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4822799 | B | Relative Binding affinity to human ERalpha LBD measured after 2 hrs by competitive fluorometric binding assay relative to estradiol | Homo sapiens | 27 | ALA4819131 | single protein format | Scientific Literature | |
2. | ALA4822800 | B | Relative Binding affinity to human ERbeta LBD measured after 2 hrs by competitive fluorometric binding assay relative to estradiol | Homo sapiens | 27 | ALA4819131 | single protein format | Scientific Literature | |
3. | ALA4822801 | B | Selectivity ratio of relative binding affinity for human ERalpha LBD to relative binding affinity for human ERbeta LBD | Homo sapiens | 27 | ALA4819131 | assay format | Scientific Literature | |
4. | ALA4822802 | B | Binding affinity to human ERalpha LBD assessed as inhibition constant measured after 2 hrs by microplate reader | Homo sapiens | 27 | ALA4819131 | single protein format | Scientific Literature | |
5. | ALA4822803 | B | Binding affinity to human ERbeta LBD assessed as inhibition constant measured after 2 hrs by microplate reader | Homo sapiens | 27 | ALA4819131 | single protein format | Scientific Literature | |
6. | ALA4822804 | B | Selectivity index, ratio of Ki for human ERalpha LBD to Ki for human ERbeta LBD | Homo sapiens | 27 | ALA4819131 | assay format | Scientific Literature | |
7. | ALA4822806 | B | Agonist activity at ERbeta (unknown origin) expressed in human HEK293T cells assessed as transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 17 | ALA4819131 | cell-based format | Scientific Literature | |
8. | ALA4822807 | B | Agonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 19 | ALA4819131 | cell-based format | Scientific Literature | |
9. | ALA4822808 | B | Agonist activity at ERbeta (unknown origin) expressed in human HEK293T cells assessed as transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 23 | ALA4819131 | cell-based format | Scientific Literature | |
10. | ALA4822809 | B | Antagonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 17 | ALA4819131 | cell-based format | Scientific Literature | |
11. | ALA4822811 | B | Antagonist activity at ERalpha (unknown origin) expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 21 | ALA4819131 | cell-based format | Scientific Literature | |
12. | ALA4822812 | B | Antagonist activity at human ERbeta expressed in human HEK293T cells assessed as inhibition of 17beta-estradiol-induced transcriptional activities by measuring ERE driven reporter gene expression measured after 24 hrs by dual luciferase reporter gene assay relative to 17beta-estradiol | Homo sapiens | 20 | ALA4819131 | cell-based format | Scientific Literature | |
13. | ALA4822813 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 28 | ALA4819131 | cell-based format | Scientific Literature | |
14. | ALA4822814 | F | Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Homo sapiens | 28 | ALA4819131 | cell-based format | Scientific Literature | |
15. | ALA4822815 | A | Antiproliferative activity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by MTT assay | Chlorocebus sabaeus | 28 | ALA4819131 | cell-based format | Scientific Literature | |
16. | ALA4822816 | T | Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for human MCF7 cells | 28 | ALA4819131 | assay format | Scientific Literature |