# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4812018 | Functional | Antiviral activity against PEDV 85-7 infected in Marc145 cells assessed as inhibition of viral replication by measuring reduction in mRNA level at 10 uM after 24 hrs by qPCR analysis | Porcine epidemic diarrhea virus | 3 | ALA4811237 | organism-based format | Scientific Literature | |
2. | ALA4812019 | Functional | Antiviral activity against PEDV 85-7 infected in Marc145 cells assessed as inhibition of viral transcription after 24 hrs by qPCR analysis | Porcine epidemic diarrhea virus | 3 | ALA4811237 | organism-based format | Scientific Literature | |
3. | ALA4812020 | ADME | Cytotoxicity against African green monkey MARC145 cells by CCK8 assay | Chlorocebus aethiops | 3 | ALA4811237 | cell-based format | Scientific Literature | |
4. | ALA4812021 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey MARC145 cells to EC50 for antiviral activity against PEDV 85-7 | 3 | ALA4811237 | cell-based format | Scientific Literature | ||
5. | ALA4812022 | Functional | Antiviral activity against PEDV 85-7 infected in Marc145 cells assessed as reduction in PEDV-N protein level at 10 uM by Western blotting analysis | Porcine epidemic diarrhea virus | 3 | ALA4811237 | organism-based format | Scientific Literature | |
6. | ALA4812026 | Functional | Antiviral activity against PEDV 85-7 infected in Marc145 cells assessed as down regulation of Hsc70 mRNA expression at 10 uM after 24 hrs by qPCR analysis | Porcine epidemic diarrhea virus | 3 | ALA4811237 | organism-based format | Scientific Literature | |
7. | ALA4812031 | Functional | Suppression of Hsc70 expression in African green monkey Marc145 cells assessed as Hsc70 mRNA destabilization by measuring half life at 20 uM (Rvb = 6.51 hrs) | Chlorocebus aethiops | 3 | ALA4811237 | tissue-based format | Scientific Literature |