# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4826549 | Binding | Activation of Hsf1 in human MSC-NEU cells assessed as induction of HSP70 accumulation at 1 uM incubated for 24 hrs by Western blotting analysis relative to control | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
2. | ALA4826550 | Binding | Activation of Hsf1 in human MSC-NEU cells assessed as induction of HSP90 accumulation at 1 uM incubated for 24 hrs by Western blotting analysis relative to control | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
3. | ALA4826551 | Binding | Activation of Hsf1 in human MSC-NEU cells assessed as increase in HSP70 substrate-binding chaperone activity at 1 uM incubated for 24 hrs by protein-protein interaction assay relative to control | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
4. | ALA4826552 | ADME | Cytotoxicity against human MSC-NEU cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
5. | ALA4826553 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-stimulated human MSC-NEU cells assessed as increase in cell index incubated for 48 hrs by xCELLigence RTCA analysis | Homo sapiens | 4 | ALA4825683 | tissue-based format | Scientific Literature | |
6. | ALA4826554 | Functional | Inhibition of amyloid beta (1 to 42)-induced cellular senescence in human MSC-NEU cells assessed as reduction in beta-galactosidase activity at 1 uM measured after 48 hrs by X-Gal staining based analysis relative to control | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
7. | ALA4826555 | Functional | Inhibition of amyloid beta(1 to 42)-induced apoptosis in human MSC-NEU cells assessed as reduction in caspase-3 activity at 1 uM measured after 24 hrs by fluorescence based analysis relative to control | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
8. | ALA4826556 | Functional | Inhibition of amyloid beta(1 to 42)-induced apoptosis in human MSC-NEU cells at 1 uM measured after 24 hrs by AnnexinV-Alexafluor647/propidium iodide staining based flow cytomtery relative to control | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature | |
9. | ALA4826557 | Binding | Activation of Hsf1 in human HEK293 cells transfected with Hsp70.1pr-luc plasmid at 1 uM incubated for 24 hrs by luciferase reporter gene based luminescence assay | Homo sapiens | 4 | ALA4825683 | cell-based format | Scientific Literature |