| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4824099 | B | Agonist activity at human TRPA1 expressed in HEK cells assessed as increase in menthol-induced intracellular calcium level incubated for 2 hrs by FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4824100 | B | Agonist activity at human TRPV4 expressed in HEK cells assessed as increase in GSK1016790A-induced intracellular calcium level measured after 1 hr by FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4824101 | B | Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in capsaicin-induced intracellular calcium level measured after 1 hr by FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4824102 | B | Agonist activity at human TRPM8 expressed in HEK cells assessed as increase in menthol-induced intracellular calcium level measured after 1 hr by FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4824103 | A | Efflux ratio of apparent permeability across basolateral to apical over apical to basolateral membrane in human Caco-2 cells incubated for 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4824104 | A | Apparent permeability across apical to basolateral membrane in human Caco-2 cells incubated for 30 mins by LC-MS/MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA4824105 | B | Agonist activity at human TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay | Homo sapiens | 72 | cell-based format | Scientific Literature | ||
| 8. | ALA4824107 | B | Agonist activity at mouse TRPM5 expressed in CHO-K1 cells maintained at 80 mV final holding potential by syncroPatch assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4824108 | A | Intrinsic clearance in human liver microsomes assessed per mg protein incubated up to 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 19 | microsome format | Scientific Literature | ||
| 10. | ALA4824109 | A | Intrinsic clearance in mouse liver microsomes assessed per mg protein incubated up to 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 19 | microsome format | Scientific Literature | ||
| 11. | ALA4824110 | P | Solubility of the compound in phospahte-buffered saline buffer at pH 7.4 incubated for 2 hrs by HPLC/UV analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4824111 | B | Agonist activity at human TRPM4 expressed in CHO cells assessed as increase in A23187-induced intracellular calcium level by FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4824112 | A | Protein binding in human plasma assessed as unbound fraction measured after 5 hrs by equilibrium dialysis based HPLC/UPLC-MS/MS analysis | Homo sapiens | 4 | cell-free format | Scientific Literature | ||
| 14. | ALA4824113 | A | Protein binding in rat plasma assessed as unbound fraction measured after 5 hrs by equilibrium dialysis based HPLC/UPLC-MS/MS analysis | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
| 15. | ALA4824114 | A | Drug metabolism in microsomes assessed as metabolite M1 formation | 1 | microsome format | Scientific Literature | |||
| 16. | ALA4824115 | A | Drug metabolism in microsomes assessed as metabolite M2 formation | 1 | microsome format | Scientific Literature |
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