| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4828188 | B | Inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 2. | ALA4828189 | A | Inhibition of recombinant human N-terminal His6-tagged full length P110alpha/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 3. | ALA4828190 | A | Inhibition of recombinant human N-terminal His6-tagged full length P110beta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 4. | ALA4828191 | B | Inhibition of recombinant human N-terminal His6-tagged full length P120gamma expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by HTRF assay | Homo sapiens | 34 | cell-based format | Scientific Literature | ||
| 5. | ALA4828192 | B | Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytostim stimulation and measured after 20 hrs by electrochemiluminescence assay | Homo sapiens | 34 | tissue-based format | Scientific Literature | ||
| 6. | ALA4828193 | A | Binding affinity to human serum albumin by HPLC analysis | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 7. | ALA4828194 | B | Selectivity ratio of IC50 for inhibition of recombinant human N-terminal His6-tagged full length P110delta/full length untagged human p85alpha expressed in baculovirus infected Sf21 insect cells to IC50 for inhibition of PI3Kdelta in human whole blood | Homo sapiens | 2 | cell-based format | Scientific Literature |
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