# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825484 | Functional | Antileishmanial activity against wild type Leishmania donovani promastigotes incubated for 72 hrs by resazurin dye based assay | Leishmania donovani | 8 | ALA4823323 | organism-based format | Scientific Literature | |
2. | ALA4825485 | ADME | Cytotoxicity against BALB/c mouse peritoneal macrophages assessed as reduction in cell viability incubated for 72 hrs by resazurin dye based fluorescence assay | Mus musculus | 15 | ALA4823323 | cell-based format | Scientific Literature | |
3. | ALA4825486 | Functional | Antileishmanial activity against Leishmania amazonensis MHOM/BR/77/LTB 0016 promastigotes assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay | Leishmania amazonensis | 15 | ALA4823323 | organism-based format | Scientific Literature | |
4. | ALA4825487 | Functional | Antileishmanial activity against intracellular Leishmania amazonensis MHOM/BR/77/LTB 0016 amastigotes infected in BALB/c mouse peritoneal macrophage assessed as reduced parasite growth incubated for 72 hrs by PANOTIC staining based assay | Leishmania amazonensis | 15 | ALA4823323 | organism-based format | Scientific Literature | |
5. | ALA4825488 | Functional | Antileishmanial activity against Leishmania infantum MHOM/MA/67/ITMAP-263 promastigotes assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay | Leishmania infantum | 15 | ALA4823323 | organism-based format | Scientific Literature | |
6. | ALA4825489 | Functional | Antileishmanial activity against intracellular Leishmania infantum MHOM/MA/67/ITMAP-263 amastigotes infected in BALB/c mouse peritoneal macrophage assessed as reduced parasite growth incubated for 72 hrs by PANOTIC staining based assay | Leishmania infantum | 12 | ALA4823323 | organism-based format | Scientific Literature | |
7. | ALA4825490 | Functional | Antileishmanial activity against Leishmania donovani LdBOB derived from MHOM/SD/62/1 S-CL2D promastigotes overexpressing NTR1 incubated for 72 hrs by resazurin dye based assay | Leishmania donovani | 7 | ALA4823323 | organism-based format | Scientific Literature | |
8. | ALA4825491 | Functional | Selectivity index, ratio of IC50 for antileishmanial activity against wild type Leishmania donovani promastigotes to IC50 for antileishmanial activity against Leishmania donovani LdBOB derived from MHOM/SD/62/1 S-CL2D promastigotes overexpressing NTR1 | Leishmania donovani | 7 | ALA4823323 | assay format | Scientific Literature | |
9. | ALA4825492 | Functional | Antileishmanial activity against Leishmania donovani LdBOB derived from MHOM/SD/62/1 S-CL2D promastigotes overexpressing NTR2 incubated for 72 hrs by resazurin dye based assay | Leishmania donovani | 7 | ALA4823323 | organism-based format | Scientific Literature | |
10. | ALA4825493 | Functional | Selectivity index, ratio of IC50 for antileishmanial activity against wild type Leishmania donovani promastigotes to IC50 for antileishmanial activity against Leishmania donovani LdBOB derived from MHOM/SD/62/1 S-CL2D promastigotes overexpressing NTR2 | Leishmania donovani | 7 | ALA4823323 | assay format | Scientific Literature | |
11. | ALA4825505 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against BALB/c mouse peritoneal macrophages assessed as reduction in cell viability incubated for 72 hrs by resazurin dye based fluorescence assay to IC50 for antileishmanial activity against intracellular Leishmania amazonensis MHOM/BR/77/LTB 0016 amastigotes infected in BALB/c mouse peritoneal macrophage | 11 | ALA4823323 | cell-based format | Scientific Literature | ||
12. | ALA4825506 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against BALB/c mouse peritoneal macrophages assessed as reduction in cell viability incubated for 72 hrs by resazurin dye based fluorescence assay to IC50 for antileishmanial activity against intracellular Leishmania infantum MHOM/MA/67/ITMAP-263 amastigotes infected in BALB/c mouse peritoneal macrophage | 8 | ALA4823323 | cell-based format | Scientific Literature |