# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4834365 | ADME | Inhibition of human CYP3A4 using testosterone as a substrate by LC/MS/MS analysis | Homo sapiens | 3 | ALA4831562 | single protein format | Scientific Literature | |
2. | ALA4834366 | Binding | Inhibition of Plasmodium falciparum PKG using FAM-labeled PKAtide or IP3R-derived peptide as a substrate preincubated for 15 mins followed by substrate addition and incubated for 60 mins by IMAP assay | Plasmodium falciparum | 8 | ALA4831562 | assay format | Scientific Literature | |
3. | ALA4834370 | ADME | Metabolic stability in human liver microsomes assessed as half life incubated for 60 mins in the presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | ALA4831562 | microsome format | Scientific Literature | |
4. | ALA4834371 | ADME | Metabolic stability in mouse liver microsomes assessed as half life incubated for 60 mins in the presence of NADPH by LC-MS/MS analysis | Mus musculus | 3 | ALA4831562 | microsome format | Scientific Literature | |
5. | ALA4834372 | Physicochemical | Kinetic aqueous solubility of the compound at pH 7.4 measured after 1 hr by UV/LC-MS/MS analysis | 3 | ALA4831562 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4834373 | ADME | Inhibition of human CYP2C9 using 7-methoxy-4(trifluoromethyl coumarin) as a substrate incubated for 15 mins by fluorescence based analysis | Homo sapiens | 2 | ALA4831562 | single protein format | Scientific Literature | |
7. | ALA4834374 | ADME | Inhibition of human CYP2D6 using 3-[2-(N,N-diethylamino)ethyl]-7-methoxy-4-methyl coumarin as a substrate incubated for 45 mins by fluorescence based analysis | Homo sapiens | 2 | ALA4831562 | single protein format | Scientific Literature | |
8. | ALA4834375 | Binding | Inhibition of human ERG transfected in HEK293 cells at 10 uM incubated for 15 mins by thallium flux based fluorescence analysis relative to control | Homo sapiens | 2 | ALA4831562 | cell-based format | Scientific Literature | |
9. | ALA4834378 | Functional | Antiplasmodial activity against asexual blood stage Plasmodium falciparum 3D7 | Plasmodium falciparum | 3 | ALA4831562 | organism-based format | Scientific Literature | |
10. | ALA4834379 | Functional | Antiplasmodial activity against luciferase expressing Plasmodium berghei hepatic stage sporozoites infected in HepG2 cells assessed as decrease in parasite infection incubated for 16 hrs followed by replacement with compound free medium measured after 48 hrs post infection by IVIS spectrum in vivo imaging analysis | Plasmodium berghei | 3 | ALA4831562 | organism-based format | Scientific Literature |