| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4845546 | Binding | Inhibition of GDP-loaded His-tagged KRAS G12C mutant (2 to 182 residues) (unknown origin) assessed as inhibition of SOS1-catalyzed nucleotide exchange preincubated for 1 hr followed by SOS1 addition measured after 1 hr by TR-FRET assay | Homo sapiens | 8 | ALA4842392 | single protein format | Scientific Literature | |
| 2. | ALA4845547 | Binding | Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 2 hrs by HTRF assay | Homo sapiens | 8 | ALA4842392 | cell-based format | Scientific Literature | |
| 3. | ALA4845548 | Functional | Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell proliferation incubated for 6 days by CCK8 assay | Homo sapiens | 6 | ALA4842392 | cell-based format | Scientific Literature |
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