# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825416 | Functional | Antiviral activity against ZIKV H/PF/2013 infected in human Huh7 cells assessed as decrease in viral RNA expression at 10 uM measured up to 72 hrs by renilla luciferase assay | Zika virus | 2 | ALA4823320 | organism-based format | Scientific Literature | |
2. | ALA4825417 | ADME | Cytotoxicity against human Huh-7 cells assessed as cell viability after 96 hrs by CellTiter-Glo Luminescent cell viability assay | Homo sapiens | 3 | ALA4823320 | cell-based format | Scientific Literature | |
3. | ALA4825419 | Binding | Inhibition of ZIKV NS2B-NS3 protease expressed in Escherichia coli BL21(DE3) using Boc-Gly-Arg-Arg-AMC as substrate by FRET assay | Zika virus | 27 | ALA4823320 | assay format | Scientific Literature | |
4. | ALA4825422 | Binding | Inhibition of DENV2 NS2B-NS3 protease expressed in Escherichia coli BL21(DE3) using Boc-Gly-Arg-Arg-AMC as substrate by FRET assay | dengue virus type 2 | 20 | ALA4823320 | assay format | Scientific Literature | |
5. | ALA4825427 | Binding | Inhibition of Trypsin (unknown origin) assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Homo sapiens | 7 | ALA4823320 | protein format | Scientific Literature | |
6. | ALA4825428 | Binding | Inhibition of Thrombin (unknown origin) assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Homo sapiens | 7 | ALA4823320 | single protein format | Scientific Literature | |
7. | ALA4825429 | Binding | Inhibition of Chymotrypsin (unknown origin) assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Homo sapiens | 7 | ALA4823320 | protein format | Scientific Literature | |
8. | ALA4825430 | Binding | Inhibition of Urokinase plasminogen activator (unknown origin) assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Homo sapiens | 7 | ALA4823320 | single protein format | Scientific Literature | |
9. | ALA4825431 | Binding | Inhibition of SARS-CoV-2 Main protease assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Severe acute respiratory syndrome coronavirus 2 | 7 | ALA4823320 | assay format | Scientific Literature | |
10. | ALA4825432 | Binding | Inhibition of Rhodesain (unknown origin) assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Not specified | 7 | ALA4823320 | assay format | Scientific Literature | |
11. | ALA4825433 | Binding | Inhibition of staphylococcus aureus Sortase A protease assessed as residual enzyme activity at 20 uM by FRET assay relative to control | Staphylococcus aureus | 7 | ALA4823320 | single protein format | Scientific Literature | |
12. | ALA4825434 | Physicochemical | Chemical stability of compound in tris assay buffer at pH 9 measured after 15 mins by HPLC/MS analysis | 6 | ALA4823320 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4825435 | Physicochemical | Chemical stability of compound in tris assay buffer at pH 9 measured after 90 mins by HPLC/MS analysis | 6 | ALA4823320 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4825436 | Physicochemical | Chemical stability of compound in tris assay buffer at pH 9 measured after 20 hrs by HPLC/MS analysis | 6 | ALA4823320 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4825437 | Physicochemical | Chemical stability of compound in cell culture conditions at pH 7.4 HEPES buffer measured after 15 mins by HPLC/MS analysis | 6 | ALA4823320 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA4825438 | Physicochemical | Chemical stability of compound in cell culture conditions at pH 7.4 HEPES buffer measured after 90 mins by HPLC/MS analysis | 6 | ALA4823320 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA4825439 | Physicochemical | Chemical stability of compound in cell culture conditions at pH 7.4 HEPES buffer measured after 20 hrs by HPLC/MS analysis | 6 | ALA4823320 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA4825440 | Functional | Antiviral activity against DENV2 New Guinea C infected in human Huh7 cells assessed as decrease in viral RNA expression at 10 uM measured up to 72 hrs by firefly luciferase assay | dengue virus type 2 | 5 | ALA4823320 | organism-based format | Scientific Literature |