# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4811564 | Binding | Inhibition of human ALDH1A1 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery | Homo sapiens | 38 | ALA4811219 | single protein format | Scientific Literature | |
2. | ALA4811565 | Binding | Inhibition of human ALDH1A2 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery | Homo sapiens | 34 | ALA4811219 | single protein format | Scientific Literature | |
3. | ALA4811566 | Binding | Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery | Homo sapiens | 35 | ALA4811219 | single protein format | Scientific Literature | |
4. | ALA4811567 | ADME | Stability in CD-1 mouse liver microsome assessed as half life at 20 uM measured upto 60 mins by LC-MS/MS analysis | Mus musculus | 18 | ALA4811219 | microsome format | Scientific Literature | |
5. | ALA4811568 | Binding | Inhibition of ALDH1A3 in human PEO1 cells at 1 uM after 30 mins by flow cytometry based ALDEFLUOR assay relative to control | Homo sapiens | 20 | ALA4811219 | cell-based format | Scientific Literature | |
6. | ALA4811575 | ADME | Observed AUC (0-7 hrs) in CD-1 mouse at 10 mg/kg, ip by LC-MS/MS analysis | Mus musculus | 6 | ALA4811219 | organism-based format | Scientific Literature | |
7. | ALA4811576 | ADME | Half life in CD-1 mouse at 10 mg/kg, ip at 2 to 4 hrs by LC-MS/MS analysis | Mus musculus | 6 | ALA4811219 | organism-based format | Scientific Literature | |
8. | ALA4811577 | ADME | Cmax in CD-1 mouse at 10 mg/kg, ip upto 7 hrs by LC-MS/MS analysis | Mus musculus | 6 | ALA4811219 | organism-based format | Scientific Literature | |
9. | ALA4811580 | Binding | Inhibition of ALDH1A1 in human OV-90 cells at 1 uM after 30 mins by flow cytometry based ALDEFLUOR assay relative to control | Homo sapiens | 4 | ALA4811219 | cell-based format | Scientific Literature | |
10. | ALA4811581 | Functional | Cytotoxicity against human SK-OV-3 cells assessed as cell viability incubated for 72 hrs relative to control | Homo sapiens | 4 | ALA4811219 | cell-based format | Scientific Literature | |
11. | ALA4811582 | Binding | Reversal of ALDH1A1-mediated drug resistance in human SKOV-3 cells assessed as potentiation of taxol-induced cytotoxicity by measuring cell viability at 50 nM incubated for 72 hrs relative to control | Homo sapiens | 4 | ALA4811219 | cell-based format | Scientific Literature | |
12. | ALA4811583 | Binding | Reversal of ALDH1A1-mediated drug resistance in human SKOV-3 cells assessed as potentiation of taxol-induced cytotoxicity by measuring cell viability at 100 nM incubated for 72 hrs relative to control | Homo sapiens | 4 | ALA4811219 | cell-based format | Scientific Literature |