# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4808885 | B | Displacement of 125I-glucagon from human GCGR expressed in HEK293 cells membranes incubated for 6 hrs by liquid scintillation counting method | Homo sapiens | 27 | cell membrane format | Scientific Literature | ||
2. | ALA4808886 | F | Antagonist activity at human GCGR expressed in HEK293 cells assessed as inhibition of glucogon-induced cAMP production | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
3. | ALA4808892 | F | Antagonist activity at human GCGR expressed in HEK293 cells assessed as inhibition of glucogon-induced cAMP production relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4808893 | F | Antagonist activity at human GIPR expressed in HEK293 cells assessed as inhibition of GIP-induced cAMP production | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
5. | ALA4808894 | F | Antagonist activity at human GIPR expressed in HEK293 cells assessed as inhibition of GIP-induced cAMP production relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4808895 | F | Antagonist activity at human GLP-1R expressed in HEK293 cells assessed as inhibition of GLP1-induced cAMP production | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4808896 | F | Antagonist activity at human GLP-1R expressed in HEK293 cells assessed as inhibition of GLP1-induced cAMP production relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
8. | ALA4808897 | F | Antagonist activity at mouse GCGR expressed in CHO-K1 cells assessed as inhibition of glucogon-induced cAMP production relative to control | Mus musculus | 2 | cell-based format | Scientific Literature | ||
9. | ALA4808898 | F | Antagonist activity at mouse GCGR expressed in CHO-K1 cells assessed as inhibition of glucogon-induced cAMP production | Mus musculus | 2 | cell-based format | Scientific Literature | ||
10. | ALA4808899 | B | Antagonist activity at mouse GIPR expressed in CHO-K1 cells assessed as inhibition of GIP-induced cAMP production | Mus musculus | 2 | cell-based format | Scientific Literature | ||
11. | ALA4808900 | B | Antagonist activity at mouse GIPR expressed in CHO-K1 cells assessed as inhibition of GIP-induced cAMP production relative to control | Mus musculus | 2 | cell-based format | Scientific Literature | ||
12. | ALA4808901 | F | Antagonist activity at mouse GLP1R expressed in CHO-K1 cells assessed as inhibition of GLP1-induced cAMP production | Mus musculus | 2 | cell-based format | Scientific Literature | ||
13. | ALA4808902 | F | Antagonist activity at mouse GLP1R expressed in CHO-K1 cells assessed as inhibition of GLP1-induced cAMP production relative to control | Mus musculus | 2 | cell-based format | Scientific Literature | ||
14. | ALA4808903 | F | Inhibition of IUB288-induced glucose elevation in C57BL/6 mouse at 1500 nmol/kg, sc pretreated for 15 mins followed by IUB288 stimulation and measured upto 120 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4808906 | T | Toxicity in C57BL/6 mouse assessed as adverse local and systemic responses at 1500 nmol/kg, sc | Mus musculus | 2 | assay format | Scientific Literature | ||
16. | ALA4808907 | A | Half life in C57BL/6 mouse at 1500 nmol/kg, sc measured upto 240 mins by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4808909 | A | Cmax in C57BL/6 mouse at 1500 nmol/kg, sc measured upto 240 mins by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4808911 | A | AUC in C57BL/6 mouse at 1500 nmol/kg, sc measured upto 240 mins by LC-MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4808913 | P | Aqueous solubility of the compound at pH 8 by LC-MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
20. | ALA4808914 | P | Chemical stability of compound in PBS buffer incubated for 5 to 7 days by LC-MS analysis | 2 | small-molecule physicochemical format | Scientific Literature |