# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4826172 | Functional | Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Y infected in LLC-MK2 cells assessed as parasite growth inhibition by resazurin assay | Trypanosoma cruzi | 4 | ALA4825666 | organism-based format | Scientific Literature | |
2. | ALA4826173 | ADME | Cytotoxicity against mouse NCTC clone 929 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Mus musculus | 4 | ALA4825666 | cell-based format | Scientific Literature | |
3. | ALA4826174 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against mouse NCTC clone 929 cells to IC50 for trypomastigote forms of Trypanosoma cruzi Y infected in LLC-MK2 cells | 4 | ALA4825666 | cell-based format | Scientific Literature | ||
4. | ALA4826183 | Binding | Induction of plasma membrane depolarization in trypomastigote forms of Trypanosoma cruzi Y at IC50 measured after 2 hrs by DiSBAC2(3)-probe based assay | Trypanosoma cruzi | 3 | ALA4825666 | cell membrane format | Scientific Literature | |
5. | ALA4826184 | ADME | Substrate activity at P-gp (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
6. | ALA4826185 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
7. | ALA4826186 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
8. | ALA4826187 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
9. | ALA4826188 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature | |
10. | ALA4826189 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | ALA4825666 | single protein format | Scientific Literature |