# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4843990 | Binding | Inhibition of recombinant human full-length PARP-1 using biotinylated substrate | Homo sapiens | 56 | ALA4842357 | single protein format | Scientific Literature | |
2. | ALA4843991 | Binding | Inhibition of recombinant human full-length PARP-2 using biotinylated substrate | Homo sapiens | 56 | ALA4842357 | single protein format | Scientific Literature | |
3. | ALA4843992 | Binding | Selectivity index, ratio of IC50 for inhibition of recombinant human full-length PARP-2 to IC50 for inhibition of recombinant human full-length PARP-1 | Homo sapiens | 56 | ALA4842357 | assay format | Scientific Literature | |
4. | ALA4843993 | Functional | Cytotoxicity against human A549 cells assessed as induction of CBP cytotoxicity incubated for 48 hrs in presence of CBP by MTT assay | Homo sapiens | 4 | ALA4842357 | cell-based format | Scientific Literature | |
5. | ALA4843994 | Functional | Cytotoxicity against human A549 cells assessed as reduction in cell viability at 0.1 to 10 uM incubated for 48 hrs by MTT assay | Homo sapiens | 4 | ALA4842357 | cell-based format | Scientific Literature | |
6. | ALA4843995 | Functional | Cytotoxicity against human BRCA-1 deficient SK-OV-3 cells assessed as reduction in cell viability at 0.1 to 10 uM incubated for 48 hrs by MTT assay | Homo sapiens | 4 | ALA4842357 | cell-based format | Scientific Literature | |
7. | ALA4843996 | Toxicity | Acute toxicity in ICR mouse assessed as death at 1000 mg/kg, po administered only once at day 1 and measured after 5 to 8 days | Mus musculus | 1 | ALA4842357 | organism-based format | Scientific Literature |