| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4835172 | B | Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assay | Homo sapiens | 60 | single protein format | Scientific Literature | ||
| 2. | ALA4835174 | B | Inhibition of human recombinant ADAMTS-1 (AA253 to 734) assessed as cleavage of fluorescent substrate using 5(6)-fluorescein-NH-AELQGRPISIAK-5(6)-TAMRA as substrate incubated for 120 mins by biochemical assay | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 3. | ALA4835175 | B | Inhibition of human recombinant ADAMTS-4 (AA1 to 520) assessed as cleavage of fluorescent substrate using as TBIS-1 substrate incubated for 180 mins by biochemical assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 4. | ALA4835176 | B | Inhibition of human recombinant MMP2 (AA34 to 660) assessed as cleavage of fluorescent substrate using 390 MMP FRET as substrate incubated for 30 mins by biochemical assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 5. | ALA4835178 | B | Inhibition of human recombinant TACE (AA34 to 660) assessed as cleavage of fluorescent substrate using 5FAM-LAQAVRSSSRK-5TAMRA as substrate by biochemical assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 6. | ALA4835204 | A | AUC in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 7. | ALA4835205 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 8. | ALA4835206 | B | Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 in absence of serum by biochemical assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 9. | ALA4835207 | B | Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 in presence of 2% HSA by biochemical assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 10. | ALA4835208 | B | Ratio of IC50 for human recombinant ADAMTS-5 in presence of 2% HSA to human recombinant ADAMTS-5 in absence of serum | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 11. | ALA4835209 | A | Plasma protein binding in human at 5 uM measured after 4 hrs by LC-MS/MS analysis | Homo sapiens | 6 | cell-free format | Scientific Literature |
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