# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4827162 | A | Cytotoxicity against rat L6 cells by Alamar blue assay | Rattus norvegicus | 16 | cell-based format | Scientific Literature | ||
2. | ALA4827163 | B | Binding affinity to poly (dA-dT) (unknown origin) assessed as thermal stability by measuring change in melting temperature | Not specified | 10 | nucleic acid format | Scientific Literature | ||
3. | ALA4827164 | F | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 measured after 72 hrs by alamar blue dye based fluorimetry analysis | Trypanosoma brucei rhodesiense | 16 | organism-based format | Scientific Literature | ||
4. | ALA4827165 | F | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation measured after 24 hrs by liquid scintillation counting method | Plasmodium falciparum | 16 | organism-based format | Scientific Literature | ||
5. | ALA4827166 | T | Selectivity index, ratio of IC50 for cytotoxicity against rat L6 cells to IC50 for antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 | 16 | cell-based format | Scientific Literature | |||
6. | ALA4827167 | T | Selectivity index, ratio of IC50 for cytotoxicity against rat L6 cells to IC50 for antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells | 16 | cell-based format | Scientific Literature | |||
7. | ALA4827168 | F | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as reduction in parasitemia by measuring time taken to cure at 5 mg/kg, ip measured up to 60 days (Rvb = 11 days) | Trypanosoma brucei rhodesiense | 10 | organism-based format | Scientific Literature |