| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4829376 | B | Inhibition of human 20S proteasome LMP2 using Ac-PAL-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assay | Homo sapiens | 20 | ALA4828720 | single protein format | Scientific Literature | |
| 2. | ALA4829377 | B | Inhibition of human 20S proteasome Y using Ac-nLPnLD-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assay | Homo sapiens | 20 | ALA4828720 | assay format | Scientific Literature | |
| 3. | ALA4829378 | B | Inhibition of human 20S proteasome LMP7 using Ac-ANW-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assay | Homo sapiens | 20 | ALA4828720 | single protein format | Scientific Literature | |
| 4. | ALA4829379 | B | Inhibition of human 20S proteasome X using Ac-WLA-AMC as fluorogenic substrate measured every minute for 1 hr by fluorescence assay | Homo sapiens | 20 | ALA4828720 | assay format | Scientific Literature | |
| 5. | ALA4829383 | B | Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells using Ac-PAL-AMC as fluorogenic substrate incubated for 72 hrs by fluorescence assay | Homo sapiens | 7 | ALA4828720 | cell-based format | Scientific Literature | |
| 6. | ALA4829384 | B | Inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells overexpressing ABCB1 using Ac-PAL-AMC as fluorogenic substrate incubated for 72 hrs by fluorescence assay | Homo sapiens | 7 | ALA4828720 | cell-based format | Scientific Literature | |
| 7. | ALA4829385 | B | Selectivity index, ratio of IC50 for inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells overexpressing ABCB1 to IC50 for inhibition of human 20S proteasome LMP2 activity in human RPMI-8226 cells | Homo sapiens | 5 | ALA4828720 | cell-based format | Scientific Literature | |
| 8. | ALA4829386 | B | Inhibition of human 20S proteasome LMP2 activity in human NCI/ADR-RES cells overexpressing ABCB1 using Ac-PAL-AMC as fluorogenic substrate incubated for 72 hrs in presence and absence of verapamil by fluorescence assay | Homo sapiens | 1 | ALA4828720 | cell-based format | Scientific Literature | |
| 9. | ALA4829388 | B | Inhibition of ABCG2 (unknown origin) expressed in MDCK-II cells assessed as reduction in pheophorbide A accumulation at 2 to 5 uM pre-incubated for 30 mins followed by wash out and once again compound addition for 45 mins by flow cytometry analysis | Homo sapiens | 1 | ALA4828720 | cell-based format | Scientific Literature | |
| 10. | ALA4829389 | B | Inhibition of human 20S proteasome LMP2 activity in MDCK-II cells using Ac-PAL-AMC as fluorogenic substrate by fluorescence assay | Homo sapiens | 1 | ALA4828720 | cell-based format | Scientific Literature | |
| 11. | ALA4829390 | B | Inhibition of human 20S proteasome LMP2 activity in MDCK-II cells overexpressing ABCG2 using Ac-PAL-AMC as fluorogenic substrate by fluorescence assay | Homo sapiens | 1 | ALA4828720 | cell-based format | Scientific Literature | |
| 12. | ALA4829391 | A | Metabolic stability in ICR mouse whole blood at 1 uM measured upto 30 mins by LC-MS/MS analysis | Mus musculus | 1 | ALA4828720 | tissue-based format | Scientific Literature | |
| 13. | ALA4829392 | A | Metabolic stability in ICR mouse liver homogenate at 1 uM measured upto 20 mins by LC-MS/MS analysis | Mus musculus | 1 | ALA4828720 | tissue-based format | Scientific Literature | |
| 14. | ALA4829393 | B | Inhibition of LMP2 in human BV-2 cells | Homo sapiens | 1 | ALA4828720 | cell-based format | Scientific Literature | |
| 15. | ALA4829394 | B | Inhibition of LMP2 in human BV-2 cells assessed as reduction in LPS-stimulated IL-1alpha release by ELISA | Homo sapiens | 1 | ALA4828720 | cell-based format | Scientific Literature | |
| 16. | ALA4829395 | A | Drug concentration in ICR mouse brain at 10 mg/kg, iv after 1 hr by LC-MS/MS analysis | Mus musculus | 1 | ALA4828720 | organism-based format | Scientific Literature | |
| 17. | ALA4829396 | B | Inhibition of LMP2 in ICR mouse brain homogenate at 10 mg/kg, iv after 1 hr | Mus musculus | 1 | ALA4828720 | organism-based format | Scientific Literature | |
| 18. | ALA4829397 | F | Cognitive enhancing effect in Tg2576 mouse assessed as shorter distances travelled before reaching the escape platform at 10 mg/kg, iv administered twice weekly and measured after 5 days by Morris water maze test | Mus musculus | 1 | ALA4828720 | organism-based format | Scientific Literature | |
| 19. | ALA4829398 | F | Cognitive enhancing effect in Tg2576 mouse assessed as reduction in escape latency at 10 mg/kg, iv administered twice weekly and measured after 5 days by Morris water maze test | Mus musculus | 1 | ALA4828720 | organism-based format | Scientific Literature | |
| 20. | ALA4829399 | F | Cognitive enhancing effect in Tg2576 mouse assessed as improvement in spatial learning and memory by measuring increase in time spent in target quadrant at 10 mg/kg, iv administered twice weekly and measured after 6 days during probe trial by Morris water maze test | Mus musculus | 1 | ALA4828720 | organism-based format | Scientific Literature |
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