# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4845008 | Binding | Inhibition of human recombinant GST-CSF1R (residues L534 to C972) expressed in Sf9 insect cells using poly(Glu,Tyr) as substrate incubated for 20 mins by ATP Kinase Glo assay | Homo sapiens | 42 | ALA4842383 | cell-based format | Scientific Literature | |
2. | ALA4845009 | Binding | Inhibition of recombinant GST-AURKA (residues Ser123 to Ser401) (unknown origin) expressed in Sf9 insect cells using tetra(-LRRASLG) peptide as substrate at 1 uM incubated for 90 mins by ATP Kinase Glo assay | Homo sapiens | 42 | ALA4842383 | cell-based format | Scientific Literature | |
3. | ALA4845010 | Binding | Inhibition of human recombinant full length GST-AURKB using tetra(-LRRASLG) peptide as substrate at 0.1 uM incubated for 20 mins by ATP Kinase Glo assay | Homo sapiens | 41 | ALA4842383 | cell-based format | Scientific Literature | |
4. | ALA4845011 | Binding | Inhibition of recombinant GST-AURKA (residues Ser123 to Ser401) (unknown origin) expressed in Sf9 insect cells using tetra(-LRRASLG) peptide as substrate incubated for 90 mins by ATP Kinase Glo assay | Homo sapiens | 8 | ALA4842383 | cell-based format | Scientific Literature | |
5. | ALA4845012 | Binding | Inhibition of human recombinant full length GST-AURKB using tetra(-LRRASLG) peptide as substrate incubated for 20 mins by ATP Kinase Glo assay | Homo sapiens | 6 | ALA4842383 | cell-based format | Scientific Literature | |
6. | ALA4845013 | Functional | Antiproliferative activity against mouse BaF3 cells transfected with human ETV6-CSF1R assessed as reduction in cell viability measured after 72 hrs by MTS method | Mus musculus | 29 | ALA4842383 | cell-based format | Scientific Literature | |
7. | ALA4845014 | Functional | Antiproliferative activity against mouse NFS-60 cells transfected with human ETV6-CSF1R assessed as reduction in cell viability measured after 72 hrs by MTS method | Mus musculus | 29 | ALA4842383 | cell-based format | Scientific Literature | |
8. | ALA4845015 | ADME | Half life in Sprague-Dawley rat at 5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
9. | ALA4845016 | ADME | Clearance in Sprague-Dawley rat at 5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
10. | ALA4845017 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
11. | ALA4845018 | ADME | Dose normalized AUC (0 to inf) in Sprague-Dawley rat at 5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
12. | ALA4845019 | ADME | Half life in Sprague-Dawley rat at 20 to 25 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
13. | ALA4845020 | ADME | Dose normalized Cmax in Sprague-Dawley rat at 20 to 25 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
14. | ALA4845021 | ADME | Tmax in Sprague-Dawley rat at 20 to 25 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
15. | ALA4845022 | ADME | Dose normalized AUC (0 to inf) in Sprague-Dawley rat at 20 to 25 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature | |
16. | ALA4845023 | ADME | Oral bioavailability in Sprague-Dawley rat at 20 to 25 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 7 | ALA4842383 | organism-based format | Scientific Literature |