# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4819518 | B | Agonist activity at HIF-2 (unknown origin) expressed in bacterial expression system assessed as change in melting temperature at 10 uM measured by thermal shift assay | Homo sapiens | 10 | ALA4818990 | assay format | Scientific Literature | |
2. | ALA4819522 | B | Agonist activity at HIF-2 in human 786-0-HRE-Luc cells assessed as increase in fluorescence intensity measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 7 | ALA4818990 | cell-based format | Scientific Literature | |
3. | ALA4833844 | B | Agonist activity at HIF-2alpha (unknown origin) expressed in 786-O cells at 2 uM measured after 24 hrs by HRE based luciferase reporter gene assay relative to control | Homo sapiens | 36 | ALA4831546 | cell-based format | Scientific Literature | |
4. | ALA4833845 | B | Agonist activity at HIF-2alpha (unknown origin) expressed in 786-O cells at 20 uM measured after 24 hrs by HRE based luciferase reporter gene assay relative to control | Homo sapiens | 36 | ALA4831546 | cell-based format | Scientific Literature | |
5. | ALA4833846 | B | Agonist activity at HIF-2alpha (unknown origin) expressed in 786-O cells measured after 24 hrs by HRE based luciferase reporter gene assay | Homo sapiens | 36 | ALA4831546 | cell-based format | Scientific Literature | |
6. | ALA5240351 | B | Binding affinity to HIF-2alpha/ARNT (unknown origin) assessed as change in melting temperature at 10 uM by protein thermal shift assay | Homo sapiens | 34 | ALA5236640 | protein format | Scientific Literature | |
7. | ALA5240352 | B | Agonist activity at human HIF-2alpha expressed in human 786-0 cells expressing HRE luciferase reporter gene assessed as increase of HIF stabilization at 20 uM incubated for 24 hrs by Steady-lumi luciferase assay | Homo sapiens | 27 | ALA5236640 | cell-based format | Scientific Literature | |
8. | ALA5240361 | B | Synergistic agonist activity at human HIF-2alpha expressed in human Hep3B cells assessed as induction of EPO transcription at 5 uM pretreated with FG4592 followed by compound addition and measured after 12 hrs by qRT-PCR analysis | Homo sapiens | 16 | ALA5236640 | cell-based format | Scientific Literature |